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Title: Evidence of natural Zika virus infection in neotropical non-human primates in Brazil
Authors: Terzian, Ana Carolina B.
Zini, Nathalia
Sacchetto, Lívia
Rocha, Rebeca Froes
Parra, Maisa Carla Pereira
Del Sarto, Juliana Lemos
Dias, Ana Carolina Fialho
Coutinho, Felipe
Rayra, Jéssica
da Silva, Rafael Alves
Costa, Vivian Vasconcelos
Fernandes, Natália Coelho Couto De Azevedo
Réssio, Rodrigo
Diaz Delgado, Josue 
Guerra, Juliana
Cunha, Mariana S.
Catão-Dias, José Luiz
Bittar, Cintia
Reis, Andréia Francesli Negri
Santos, Izalco Nuremberg Penha dos
Ferreira, Andréia Cristina Marascalchi
Cruz, Lilian Elisa Arão Antônio
Rahal, Paula
Ullmann, Leila
Malossi, Camila
Araújo, João Pessoa de
Widen, Steven
de Rezende, Izabela Maurício
Mello, Érica
Pacca, Carolina Colombelli
Kroon, Erna Geessien
Trindade, Giliane
Drumond, Betânia
Chiaravalloti-Neto, Francisco
Vasilakis, Nikos
Teixeira, Mauro M.
Nogueira, Maurício Lacerda
UNESCO Clasification: 310911 Virología
240121 Primates
Keywords: Aedes
Disease carrier, et al
Issue Date: 2018
Journal: Scientific Reports 
Abstract: In Africa, Old World Primates are involved in the maintenance of sylvatic circulation of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We hypothesized that free-living NHPs might play a role in urban/periurban ZIKV dynamics, thus we undertook an NHP ZIKV investigation in two cities in Brazil. We identified ZIKV-positive NHPs and sequences obtained were phylogenetically related to the American lineage of ZIKV. Additionally, we inoculated four C. penicillata with ZIKV and our results demonstrated that marmosets had a sustained viremia. The natural and experimental infection of NHPs with ZIKV, support the hypothesis that NHPs may be a vertebrate host in the maintainance of ZIKV transmission/circulation in urban tropical settings. Further studies are needed to understand the role they may play in maintaining the urban cycle of the ZIKV and how they may be a conduit in establishing an enzootic transmission cycle in tropical Latin America.
ISSN: 2045-2322
DOI: 10.1038/s41598-018-34423-6
Source: Scientific Reports [ISSN 2045-2322], v. 8 (16034), p. 1-15
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