Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/45699
Título: Targeting essential Eimeria ninakohlyakimovae sporozoite ligands for caprine host endothelial cell invasion with a phage display peptide library
Autores/as: Ruiz Reyes, Antonio 
Pérez Barreto,Davinia 
Muñoz Ojeda, María Del Carmen 
Molina Caballero, José Manuel 
Taubert, Anja
Jacobs-Lorena, Marcelo
Vega-Rodríguez, Joel
López González, Adassa María 
Hermosilla, Carlos R.
Clasificación UNESCO: 240112 Parasitología animal
Palabras clave: Membrane Antigen 1
Proteins
Goats
Bovis
Eimeria ninakohlyakimovae, et al.
Fecha de publicación: 2015
Editor/a: 0932-0113
Publicación seriada: Parasitology Research 
Resumen: Eimeria ninakohlyakimovae is an important coccidian parasite of goats which causes severe diarrhoea in young animals. Specific molecules that mediate E. ninakohlyakimovae host interactions and molecular mechanisms involved in the pathogenesis are still unknown. Although strong circumstantial evidence indicates that E. ninakohlyakimovae sporozoite interactions with caprine endothelial host cells (ECs) are specific, hardly any information is available about the interacting molecules that confer host cell specificity. In this study, we describe a novel method to identify surface proteins of caprine umbilical vein endothelial cells (CUVEC) using a phage display library. After several panning rounds, we identified a number of peptides that specifically bind to the surface of CUVEC. Importantly, caprine endothelial cell peptide 2 (PCEC2) and PCEC5 selectively reduced the infection rate by E. ninakohlyakimovae sporozoites. These preliminary data give new insight for the molecular identification of ligands involved in the interaction between E. ninakohlyakimovae sporozoites and host ECs. Further studies using this phage approach might be useful to identify new potential target molecules for the development of anti-coccidial drugs or even new vaccine strategies.
URI: http://hdl.handle.net/10553/45699
ISSN: 0932-0113
DOI: 10.1007/s00436-015-4666-x
Fuente: Parasitology Research [ISSN 0932-0113], v. 114, p. 4327-4331
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