Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45511
DC FieldValueLanguage
dc.contributor.authorSantos, E.
dc.contributor.authorRomero-Aleman, M. M.
dc.contributor.authorMonzón-Mayor, M.
dc.contributor.authorLang, D. M.
dc.contributor.authorRodger, J.
dc.contributor.authorYanes, C.
dc.contributor.otherROMERO-ALEMAN, MARIA DEL MAR
dc.contributor.otherLang, Dirk
dc.contributor.otherRodger, Jennifer
dc.contributor.otherMonzon-Mayor, Maximina
dc.date.accessioned2018-11-22T10:25:12Z-
dc.date.available2018-11-22T10:25:12Z-
dc.date.issued2011
dc.identifier.issn1932-8451
dc.identifier.urihttp://hdl.handle.net/10553/45511-
dc.description.abstractRetinal ganglion cell (RGC) axons regrow spontaneously after optic nerve (ON) transection in G. galloti. Because brain-derived neurotrophic factor (BDNF) is considered the major neurotrophin participating in vertebrate visual system development and promotes RGC survival, we investigated its distribution using dual-labeling immunohistochemistry for neuronal and glial markers. We examined the developing and regenerating lizard visual system at 1, 3, 6, 9, and 12 months postlesion to comparatively evaluate BDNF expression patterns. BDNF was detected from midembryonic stages (E35) in both retinal plexiform layers, and in radial glial processes in the tectum. Moreover, RGC axon staining was detected at late prenatal stages (E39), showing a transient punctate staining which progressed in a temporo-spatial pattern that was similar to myelination. Strong expression in RGC axons was maintained in adults. However, transient downregulation of BDNF staining occurred on the experimental side one month after ON transection followed by a gradual recovery with extensive punctate/swelling distribution and persistent upregulation at 12 months. Conversely, quantitative PCR analysis for 1 and 12 months regenerate lizards showed downregulation of the ratio of BDNF mRNA expression at 12 months and nonsignificant changes of NT-3 transcripts. In summary, we demonstrate that BDNF and NT-3 are abundantly expressed during lizard visual system ontogeny and regeneration suggesting their participation in the development, maintenance and plasticity of the system. (C) 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 836-853, 2011
dc.publisher1932-8451
dc.relation.ispartofDevelopmental Neurobiology
dc.sourceDevelopmental Neurobiology[ISSN 1932-8451],v. 71 (10), p. 836-853
dc.subject.otherRetinal Ganglion-Cells
dc.subject.otherOptic-Nerve Regeneration
dc.subject.otherNeurotrophic Factor Bdnf
dc.subject.otherMessenger-Rna
dc.subject.otherGlutamine-Synthetase
dc.subject.otherRetinotectal System
dc.subject.otherProtein Expression
dc.subject.otherAxonal-Transport
dc.subject.otherMultiple Roles
dc.subject.otherGlial-Cells
dc.titleExpression of BDNF and NT-3 during the ontogeny and regeneration of the lacertidian (Gallotia galloti) visual system
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1002/dneu.20939
dc.identifier.scopus80052642945-
dc.identifier.isi000295174600003
dcterms.isPartOfDevelopmental Neurobiology
dcterms.sourceDevelopmental Neurobiology[ISSN 1932-8451],v. 71 (10), p. 836-853
dc.contributor.authorscopusid35084324600
dc.contributor.authorscopusid6506533545
dc.contributor.authorscopusid36793900900
dc.contributor.authorscopusid7202375282
dc.contributor.authorscopusid7005395616
dc.contributor.authorscopusid7004187530
dc.description.lastpage853
dc.description.firstpage836
dc.relation.volume71
dc.type2Artículoes
dc.identifier.wosWOS:000295174600003
dc.contributor.daisngid2816094
dc.contributor.daisngid1157526
dc.contributor.daisngid901526
dc.contributor.daisngid626938
dc.contributor.daisngid34721664
dc.contributor.daisngid78901
dc.contributor.daisngid675718
dc.identifier.investigatorRIDK-8038-2014
dc.identifier.investigatorRIDI-2554-2015
dc.identifier.investigatorRIDNo ID
dc.identifier.investigatorRIDNo ID
dc.contributor.wosstandardWOS:Santos, E
dc.contributor.wosstandardWOS:Romero-Aleman, MM
dc.contributor.wosstandardWOS:Monzon-Mayor, M
dc.contributor.wosstandardWOS:Lang, DM
dc.contributor.wosstandardWOS:Rodger, J
dc.contributor.wosstandardWOS:Yanes, C
dc.date.coverdateOctubre 2011
dc.identifier.ulpgces
dc.description.sjr2,171
dc.description.jcr3,551
dc.description.sjrqQ2
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUIBS: Tecnología Médica y Audiovisual-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-7987-5509-
crisitem.author.orcid0000-0002-5046-508X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRomero Alemán, María Del Mar-
crisitem.author.fullNameMonzón Mayor,Maximina-
crisitem.author.fullNameYanes Mendez, Carmen M-
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