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Title: Myocardial damage in dogs affected by heartworm disease (Dirofilaria immitis): Immunohistochemical study of cardiac myoglobin and troponin I in naturally infected dogs
Authors: Carretón Gomez, Elena 
Grandi, G.
Morchon Garcia,Rodrigo 
Simón Martín,Fernando 
Passeri, B.
Cantoni, A. M.
Kramer, L.
Montoya Alonso, José Alberto 
UNESCO Clasification: 240112 Parasitología animal
310907 Patología
Keywords: Dirofilaria immitis
Cardiac troponin I
Issue Date: 2012
Publisher: 0304-4017
Journal: Veterinary Parasitology 
Abstract: It has recently been reported that dogs affected by canine heartworm disease (Dirofilaria immitis) can show an increase in plasma levels of myoglobin and cardiac troponin I, two markers of muscle/myocardial injury. In order to determine if this increase is due to myocardial damage, the right ventricle of 24 naturally infected dogs was examined by routine histology and immunohistochemistry with anti-myoglobin and anti-cardiac troponin I antibodies. Microscopic lesions included necrosis and myocyte vacuolization, and were associated with loss of staining for one or both proteins. Results confirm that increased levels of myoglobin and cardiac troponin I are indicative of myocardial damage in dogs affected by heartworm disease.
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2012.04.013
Source: Veterinary Parasitology [ISSN 0304-4017], v. 189, p. 390-393
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