Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/45358
Título: D-dimer deposits in lungs and kidneys suggest its use as a marker in the clinical workup of dogs with heartworm (dirofilaria immitis) disease
Autores/as: Carretón Gomez, Elena 
González-Miguel, J.
Montoya Alonso, José Alberto 
Morchon Garcia,Rodrigo 
Simón Martín,Fernando 
Passeri, B.
Cantoni, A. M.
Kramer, L.
Clasificación UNESCO: 310907 Patología
240112 Parasitología animal
Palabras clave: Dirofilaria immitis
Tromoboembolism
D-Dimer
Lung
Kidney, et al.
Fecha de publicación: 2013
Editor/a: 0304-4017
Publicación seriada: Veterinary Parasitology 
Resumen: It has been reported that dogs with heartworm disease (Dirofilaria immitis) show increased plasma levels of D-dimer, a fibrin degradation product present in the blood after a blood clot is degraded by fibrinolysis. In the present study the authors show that, in dogs with both experimental and natural infections with D. immitis, D-dimer deposits in lungs and kidneys are associated with pulmonary thromboembolism and microfilariemic status, as well as there was a clear association between increased plasma values of D-dimer and positive staining in immunohistochemistry. Results suggest that the monitoring of D-dimer levels in infected dogs could be useful in evaluating the presence of pulmonary thromboembolism in the lungs and that microfilariae may induce microthrombosis in kidneys, thus contributing to renal pathology.
URI: http://hdl.handle.net/10553/45358
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2012.08.008
Fuente: Veterinary Parasitology [ISSN 0304-4017], v. 191, p. 182-186
Colección:Artículos
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