Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/45307
Title: | Bovine growth hormone induces oscillations in cytosolic free Ca2+ in single rat hepatocytes | Authors: | Marrero, Isabel Green, Anne K. Cobbold, Peter H. Dixon, C. Jane |
UNESCO Clasification: | 32 Ciencias médicas 320502 Endocrinología |
Keywords: | Hormone Cytosolic Rat hepatocytes |
Issue Date: | 1996 | Journal: | Biochemical Journal | Abstract: | Single rat hepatocytes microinjected with the photoprotein aequorin generate oscillations in the cytosolic free Ca2+ concentration ([Ca2+]i) when stimulated with agonists acting through the phosphoinositide signalling pathway. We show here that, in single rat hepatocytes, bovine growth hormone (bGH) is able to induce [Ca2+]i oscillations which display similarities with oscillations induced by phenylephrine. Thus the rate of rise of intracellular Ca2+ in each oscillation closely resembles that induced by Ins(1,4,5)P3-mediated agonists. However, the duration of bGH-induced oscillations increases with agonist concentration, in contrast to phenylephrine-induced oscillations, which undergo an increase in frequency as the agonist concentration is raised, without any increase in the duration of individual oscillations. | URI: | http://hdl.handle.net/10553/45307 | ISSN: | 0264-6021 | DOI: | 10.1042/bj3130525 | Source: | Biochemical Journal [ISSN 0264-6021], v. 313, p. 525-528 |
Appears in Collections: | Artículos |
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.