|Title:||Bovine growth hormone induces oscillations in cytosolic free Ca2+ in single rat hepatocytes||Authors:||Marrero, Isabel
Green, Anne K.
Cobbold, Peter H.
Dixon, C. Jane
|UNESCO Clasification:||32 Ciencias médicas
|Issue Date:||1996||Journal:||Biochemical Journal||Abstract:||Single rat hepatocytes microinjected with the photoprotein aequorin generate oscillations in the cytosolic free Ca2+ concentration ([Ca2+]i) when stimulated with agonists acting through the phosphoinositide signalling pathway. We show here that, in single rat hepatocytes, bovine growth hormone (bGH) is able to induce [Ca2+]i oscillations which display similarities with oscillations induced by phenylephrine. Thus the rate of rise of intracellular Ca2+ in each oscillation closely resembles that induced by Ins(1,4,5)P3-mediated agonists. However, the duration of bGH-induced oscillations increases with agonist concentration, in contrast to phenylephrine-induced oscillations, which undergo an increase in frequency as the agonist concentration is raised, without any increase in the duration of individual oscillations.||URI:||http://hdl.handle.net/10553/45307||ISSN:||0264-6021||DOI:||10.1042/bj3130525||Source:||Biochemical Journal [ISSN 0264-6021], v. 313, p. 525-528|
|Appears in Collections:||Artículos|
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