Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45307
Title: Bovine growth hormone induces oscillations in cytosolic free Ca2+ in single rat hepatocytes
Authors: Marrero, Isabel 
Green, Anne K.
Cobbold, Peter H.
Dixon, C. Jane
UNESCO Clasification: 32 Ciencias médicas
320502 Endocrinología
Keywords: Hormone
Cytosolic
Rat hepatocytes
Issue Date: 1996
Journal: Biochemical Journal 
Abstract: Single rat hepatocytes microinjected with the photoprotein aequorin generate oscillations in the cytosolic free Ca2+ concentration ([Ca2+]i) when stimulated with agonists acting through the phosphoinositide signalling pathway. We show here that, in single rat hepatocytes, bovine growth hormone (bGH) is able to induce [Ca2+]i oscillations which display similarities with oscillations induced by phenylephrine. Thus the rate of rise of intracellular Ca2+ in each oscillation closely resembles that induced by Ins(1,4,5)P3-mediated agonists. However, the duration of bGH-induced oscillations increases with agonist concentration, in contrast to phenylephrine-induced oscillations, which undergo an increase in frequency as the agonist concentration is raised, without any increase in the duration of individual oscillations.
URI: http://hdl.handle.net/10553/45307
ISSN: 0264-6021
DOI: 10.1042/bj3130525
Source: Biochemical Journal [ISSN 0264-6021], v. 313, p. 525-528
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