Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44778
Title: Immunomodulatory effects of the intake of fermented milk with Lactobacillus casei DN114001 in lactating mothers and their children
Authors: Ortiz Andrellucchi, Adriana Patricia 
Sánchez-Villegas, Almudena 
Rodríguez-Gallego, Carlos 
Lemes, Angelina
Molero Labarta, María Teresa 
Soria, Adela
Peña-Quintana, Luis 
Santana, Milagrosa
Ramírez García, Octavio José 
García, José 
Cabrera Fránquiz, Félix 
Cobo, José
Serra-Majem, Lluís 
UNESCO Clasification: 32 Ciencias médicas
3206 Ciencias de la nutrición
320110 Pediatría
Keywords: Normal Human-Pregnancy
Strain Shirota
Probiotic Bacteria
Recurrent Miscarriage
Autoimmune-Diseases, et al
Issue Date: 2008
Journal: British Journal of Nutrition 
Abstract: The healthy action of probiotics is not only due to their nutritional properties and their influence on the gastrointestinal environment, but also to their action on the immune system. The aim of the present Study was to determine if 6 weeks of probiotic intake would be able to modulate the immune system in women who had recently delivered and were breast-feeding. The design consisted of a randomised, controlled and double-blind nutritional intervention study with parallel groups with a sample size of 104 women. The main variable is the T helper type 1/T helper type 2 (Th1/Th2) profile determined by measuring interferon-gamma (Th1) and IL-4 (Th2) values in peripheral blood by flow cytometry. The modifications of cytokines were evaluated in maternal milk by cytometric bead array in a flow cytometer and ELISA at three stages of breast-feeding: colostrum, early milk (10d) and mature milk (45d). Additionally, the anthropometry and infectious and allergic episodes in the newborn were followed up throughout the first 6 months of life. After the consumption of milk fermented with Lactobacillus casei during the puerperium, we observed a nonsignificant increase in T and B lymphocytes and a significant increase in natural killer cells. A decrease in the pro-inflammatory cytokine TNF-alpha in maternal milk and fewer gastrointestinal disturbances were also observed in the breast-fed child of the mothers who consumed L. casei. The intake of milk fermented with L. casei during the lactation period modestly contributes to the modulation of the mother's immunological response after delivery and decreases the incidence of gastrointestinal episodes in the breast-fed child.
URI: http://hdl.handle.net/10553/44778
ISSN: 0007-1145
DOI: 10.1017/S0007114508959183
Source: British Journal of Nutrition[ISSN 0007-1145],v. 100, p. 834-845 (Septiembre 2008)
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