Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44731
Title: Associations between lactase persistence and the metabolic syndrome in a cross-sectional study in the Canary Islands
Authors: Almon, Ricardo
Álvarez-Leon, Eva E.
Engfeldt, Peter
Serra-Majem, Lluís 
Magnuson, Anders
Nilsson, Torbjörn K.
Keywords: Insulin-Resistance
Dairy-Products
Cardiovascular-Disease
Lactose-Intolerance
Dietary Calcium, et al
Issue Date: 2010
Publisher: 1436-6207
Journal: European Journal of Nutrition 
Abstract: The single nucleotide polymorphism (SNP) LCT -13910 C > T, associated with genetically determined phenotypes of lactase persistence (LP) or non-persistence (LNP), was studied in relation to the metabolic syndrome (MS).The aim was to determine if milk intake and MS are associated. We applied Mendelian randomization (MR). The SNP, LCT -13910 C > T, with the genotypes LP (TT/CT) and LNP (CC), was taken as a proxy for milk consumption.A representative sample of adults belonging to the Canary Islands Nutrition Survey (ENCA) in Spain aged 18-75 years (n = 551) was genotyped for the LCT -13910 C > T polymorphism. We used the International Diabetes Federation (IDF) criteria to define MS.60% of the population was LP and 40% LNP. One hundred seven LP subjects (35.0%) and 53 LNP subjects (25.6%) showed MS (chi (2) = 5.04, p = 0.025). LP subjects showed a significantly higher odds ratio (OR) for MS than LNP subjects computed for the whole population: both the crude OR (1.56; 95% CI 1.06-2.31) and adjusted OR for sex, age, daily energy intake, physical activity and educational level (1.57; 95% CI 1.02-2.43). Adjusted OR for women with LP was 1.93; 95% CI 1.06-3.52.The T allele of the SNP might constitute a nutrigenetic factor increasing the susceptibility of LP subjects, especially women, to develop MS in the Canary Islands.
URI: http://hdl.handle.net/10553/44731
ISSN: 1436-6207
DOI: 10.1007/s00394-009-0058-2
Source: European Journal of Nutrition[ISSN 1436-6207],v. 49, p. 141-146
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