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Title: Effect of a traditional Mediterranean diet on apolipoproteins B, A-I, and their ratio: A randomized, controlled trial
Authors: Solá, Rosa
Fitó, Montserrat
Estruch, Ramón
Salas-Salvadó, Jordi
Corella, Dolores
de La Torre, Rafael
Muñoz, Miguel Angel
del Carmen López-Sabater, María
Martínez-González, Miguel Angel
Arós, Fernando
Ruiz-Gutierrez, Valentina
Fiol, Miquel
Casals, Elena
Wärnberg, Julia
Buil-Cosiales, Pilar
Ros, Emilio
Konstantinidou, Valentini
Lapetra, José
Serra-Majem, Lluis 
Covas, María Isabel
Keywords: Density Lipoprotein Secretion
Cardiovascular Risk-Factors
Ldl Cholesterol
Time, et al
Issue Date: 2011
Publisher: 0021-9150
Journal: Atherosclerosis 
Abstract: Objectives: Apolipoprotein (Apo) B, ApoA-I, and their ratio could predict coronary heart disease (CHD) risk more accurately than conventional lipid measurements. Our aim was to assess the effect of a traditional Mediterranean diet (TMD) on apolipoproteins.Methods: High-cardiovascular risk subjects (n = 551, 308 women and 243 men), aged 55-80 years, were recruited into a large, multicenter, randomized, controlled, parallel-group, clinical trial (The PREDIMED Study) aimed at testing the efficacy of TMD on primary cardiovascular disease prevention. Participants assigned to a low-fat diet (control) (n = 177), or TMDs (TMD + virgin olive oil (VOO), n = 181 or TMD + nuts, n = 193) received nutritional education and either free VOO (ad libitum) or nuts (dose: 30g/day). A 3-month evaluation was performed.Results: Both TMDs promoted beneficial changes on classical cardiovascular risk factors. ApoA-I increased, and ApoB and ApoB/ApoA-I ratio decreased after TMD + VOO, the changes promoting a lower cardiometabolic risk. Changes in TMD + VOO versus low-fat diet were -2.9 mg/dL (95% CI, -5.6 to -0.08), 3.3 mg/dL (95% CI, 0.84 to 5.8), and -0.03 mg/dL (-0.05 to -0.01) for ApoB, ApoA-I, and ApoB/ApoA-I ratio, respectively.Conclusions: Individuals at high-cardiovascular risk who improved their diet toward a TMD pattern rich in virgin olive oil, reduced their Apo B and ApoB/ApoA-I ratio and improved ApoA-I concentrations. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2011.04.026
Source: Atherosclerosis[ISSN 0021-9150],v. 218, p. 174-180
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