Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44705
Title: Effect of a traditional Mediterranean diet on apolipoproteins B, A-I, and their ratio: A randomized, controlled trial
Authors: Solá, Rosa
Fitó, Montserrat
Estruch, Ramón
Salas-Salvadó, Jordi
Corella, Dolores
de La Torre, Rafael
Muñoz, Miguel Angel
del Carmen López-Sabater, María
Martínez-González, Miguel Angel
Arós, Fernando
Ruiz-Gutierrez, Valentina
Fiol, Miquel
Casals, Elena
Wärnberg, Julia
Buil-Cosiales, Pilar
Ros, Emilio
Konstantinidou, Valentini
Lapetra, José
Serra-Majem, Lluis 
Covas, María Isabel
Keywords: Density Lipoprotein Secretion
Cardiovascular Risk-Factors
Myocardial-Infarction
Ldl Cholesterol
Time, et al
Issue Date: 2011
Publisher: 0021-9150
Journal: Atherosclerosis 
Abstract: Objectives: Apolipoprotein (Apo) B, ApoA-I, and their ratio could predict coronary heart disease (CHD) risk more accurately than conventional lipid measurements. Our aim was to assess the effect of a traditional Mediterranean diet (TMD) on apolipoproteins.Methods: High-cardiovascular risk subjects (n = 551, 308 women and 243 men), aged 55-80 years, were recruited into a large, multicenter, randomized, controlled, parallel-group, clinical trial (The PREDIMED Study) aimed at testing the efficacy of TMD on primary cardiovascular disease prevention. Participants assigned to a low-fat diet (control) (n = 177), or TMDs (TMD + virgin olive oil (VOO), n = 181 or TMD + nuts, n = 193) received nutritional education and either free VOO (ad libitum) or nuts (dose: 30g/day). A 3-month evaluation was performed.Results: Both TMDs promoted beneficial changes on classical cardiovascular risk factors. ApoA-I increased, and ApoB and ApoB/ApoA-I ratio decreased after TMD + VOO, the changes promoting a lower cardiometabolic risk. Changes in TMD + VOO versus low-fat diet were -2.9 mg/dL (95% CI, -5.6 to -0.08), 3.3 mg/dL (95% CI, 0.84 to 5.8), and -0.03 mg/dL (-0.05 to -0.01) for ApoB, ApoA-I, and ApoB/ApoA-I ratio, respectively.Conclusions: Individuals at high-cardiovascular risk who improved their diet toward a TMD pattern rich in virgin olive oil, reduced their Apo B and ApoB/ApoA-I ratio and improved ApoA-I concentrations. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
URI: http://hdl.handle.net/10553/44705
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2011.04.026
Source: Atherosclerosis[ISSN 0021-9150],v. 218, p. 174-180
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

62
checked on Jun 13, 2021

WEB OF SCIENCETM
Citations

57
checked on Jun 13, 2021

Page view(s)

22
checked on Jun 13, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.