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Title: Cross-sectional associations between macronutrient intake and chronic kidney disease in a population at high cardiovascular risk
Authors: Díaz-López, Andrés
Bulló, Mònica
Basora, Josep
Martínez-González, Miguel Ángel
Guasch-Ferré, Marta
Estruch, Ramon
Wärnberg, Julia
Serra-Majem, Lluís 
Arós, Fernando
Lapetra, José
Ros, Emilio
Pintó, Xavier
Covas, María Isabel
Salas-Salvadó, Jordi
Keywords: Dietary-Protein Restriction
Polyunsaturated Fatty-Acids
All-Cause Mortality
Renal-Insufficiency, et al
Issue Date: 2013
Publisher: 0261-5614
Journal: Clinical Nutrition 
Abstract: Background Ea aims: The aim was to examine the associations between macronutrient intake and the prevalence of chronic kidney disease (CKD) or microalbuminuria (MiA) in individuals at high cardiovascular risk.Methods: Cross-sectional analyses conducted in 2123 nondiabetic individuals from the PREDIMED study. Dietary data were collected using a food-frequency questionnaire. Analysis of covariance was used to assess associations between quartiles of nutrient intake and estimated glomerular filtration rate (eGFR) or urinary albumin-to-creatinine ratio (ACR). The odds ratio (OR) for the presence of CKD or MiA according to quartiles of nutrient intake was assessed by logistic regression models.Results: Individuals in the highest quartile of n-6 polyunsaturated fatty acid (PUFA) intake showed lower average eGFR. Individuals in the top quartile of fiber intake had a decreased risk of CKD [OR: 0.68; 95% CI: 0.48-0.95]. Conversely, subjects in the highest quartile of n-6 PUFA intake showed an increased risk of CKD [OR: 1.44; 95% CI: 1.03-2.01]. No significant associations were found between the intake of other macronutrients and eGFR, urinary ACR or risk of CKD or MiA.Conclusions: A high fiber intake was associated with a decreased risk of CKD, while a high n-6 PUFA intake was inversely associated with eGFR and directly associated with an increased risk of CKD. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
ISSN: 0261-5614
DOI: 10.1016/j.clnu.2012.10.013
Source: Clinical Nutrition[ISSN 0261-5614],v. 32, p. 606-612
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