Please use this identifier to cite or link to this item:
Title: Mediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: A randomized controlled trial in a high-cardiovascular-risk population
Authors: Corella, Dolores
Carrasco, Paula
Sorlí, Jose V.
Estruch, Ramón
Rico-Sanz, Jesús
Martínez-González, Miguel Ángel
Salas-Salvadó, Jordi
Covas, M. Isabel
Coltell, Oscar
Arós, Fernando
Lapetra, José
Serra-Majem, Lluís 
Ruiz-Gutiérrez, Valentina
Warnberg, Julia
Fiol, Miquel
Pintó, Xavier
Ortega-Azorín, Carolina
Muñoz, Miguel Ángel
Martínez, J. Alfredo
Gómez-Gracia, Enrique
González, José I. 
Ros, Emilio
Ordovás, José M.
Keywords: Tcf7L2 Gene
Glycemic Index
Carbohydrate, et al
Issue Date: 2013
Publisher: 0149-5992
Journal: Diabetes Care 
Abstract: OBJECTIVETranscription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) on these associations are unknown. We investigated whether the TCF7L2-rs7903146 (C>T) polymorphism associations with type 2 diabetes, glucose, lipids, and cardiovascular disease incidence were modulated by MedDiet.RESEARCH DESIGN AND METHODSA randomized trial (two MedDiet intervention groups and a control group) with 7,018 participants in the PREvencion con DIetaMEDiterranea study was undertaken and major cardiovascular events assessed. Data were analyzed at baseline and after a median follow-up of 4.8 years. Multivariable-adjusted Cox regression was used to estimate hazard ratios (HRs) for cardiovascular events.RESULTSThe TCF7L2-rs7903146 polymorphism was associated with type 2 diabetes (odds ratio 1.87 [95% CI 1.62-2.17] for TT compared with CC). MedDiet interacted significantly with rs7903146 on fasting glucose at baseline (P interaction = 0.004). When adherence to the MedDiet was low, TT had higher fasting glucose concentrations (132.3 3.5 mg/dL) than CC+CT (127.3 +/- 3.2 mg/dL) individuals (P = 0.001). Nevertheless, when adherence was high, this increase was not observed (P = 0.605). This modulation was also detected for total cholesterol, LDL cholesterol, and triglycerides (P interaction < 0.05 for all). Likewise, in the randomized trial, TT subjects had a higher stroke incidence in the control group (adjusted HR 2.91 [95% CI 1.36-6.19]; P = 0.006 compared with CC), whereas dietary intervention with MedDiet reduced stroke incidence in TT homozygotes (adjusted HR 0.96 [95% CI 0.49-1.87]; P = 0.892 for TT compared with CC).CONCLUSIONSOur novel results suggest that MedDiet may not only reduce increased fasting glucose and lipids in TT individuals, but also stroke incidence.
ISSN: 0149-5992
DOI: 10.2337/dc13-0955
Source: Diabetes Care[ISSN 0149-5992],v. 36, p. 3803-3811
Appears in Collections:Artículos
Show full item record


checked on Apr 11, 2021


checked on Apr 11, 2021

Page view(s)

checked on Apr 11, 2021

Google ScholarTM




Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.