Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44663
Title: Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study
Authors: Tresserra-Rimbau, A.
Rimm, E. B.
Medina-Remón, A.
Martínez-González, M. A.
de la Torre, R.
Corella, D.
Salas-Salvadó, J.
Gómez-Gracia, E.
Lapetra, J.
Arós, F.
Fiol, M.
Ros, E.
Serra-Majem, L. 
Pintó, X.
Saez, G. T.
Basora, J.
Sorlí, J. V.
Martínez, J. A.
Vinyoles, E.
Ruiz-Gutiérrez, V.
Estruch, R.
Lamuela-Raventós, R. M.
Keywords: Dietary-Intake
Myocardial-Infarction
Disease Mortality
Flavonoid Intake
Food Sources, et al
Issue Date: 2014
Publisher: 0939-4753
Journal: Nutrition, Metabolism and Cardiovascular Diseases 
Abstract: Background and aims: Epidemiologic and biological evidence supports an inverse association between polyphenol consumption and the risk of cardiovascular disease (CVD). However, no previous studies have prospectively evaluated the relationship between polyphenol intake and the incidence of CVD in such a comprehensive way. The aim was to evaluate the association between intakes of total polyphenol and polyphenol subgroups, and the risk of major cardiovascular events (myocardial infarction, stroke or death from cardiovascular causes) in the PREDIMED study.Methods and results: The present work is an observational study within the PREDIMED trial. Over an average of 4.3 years of follow-up, there were 273 confirmed cases of CVD among the 7172 participants (96.3%) who completed a validated 137-item food frequency questionnaire (FFQ) at baseline. Polyphenol consumption was calculated by matching food consumption data from the FFQ with the Phenol-Explorer database on polyphenol content of each reported food. After multivariate adjustment, a 46% reduction in risk of CVD risk was observed comparing Q5 vs. Q1 of total polyphenol intake (HR = 0.54; 95% confidence interval [CI] = 0.33-0.91; P-trend = 0.04). The polyphenols with the strongest inverse associations were flavanols (HR = 0.40; CI 0.23-0.72; P-trend = 0.003), lignans (HR = 0.51; CI 0.30-0.86; P-trend = 0.007), and hydroxybenzoic acids (HR = 0.47; CI 0.26-0.86; P-trend 0.02).Conclusion: Greater intake of polyphenols, especially from lignans, flavanols, and hydroxybenzoic acids, was associated with decreased CVD risk. Clinical trials are needed to confirm this effect and establish accurate dietary recommendations. Clinical trial registry: International Standard Randomized Controlled Trial Number (ISRCTN of London, England) 35739639. (C) 2014 Elsevier B. V. All rights reserved.
URI: http://hdl.handle.net/10553/44663
ISSN: 0939-4753
DOI: 10.1016/j.numecd.2013.12.014
Source: Nutrition, Metabolism and Cardiovascular Diseases[ISSN 0939-4753],v. 24, p. 639-647
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

168
checked on May 16, 2021

WEB OF SCIENCETM
Citations

156
checked on May 16, 2021

Page view(s)

11
checked on May 16, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.