Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44661
Title: MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial
Authors: Corella, Dolores
Sorlí, Jose V.
Estruch, Ramon
Coltell, Oscar
Ortega-Azorín, Carolina
Portolés, Olga
Martínez-González, Miguel Ángel
Bulló, Mónica
Fitó, Montserrat
Arós, Fernando
Lapetra, José
Asensio, Eva M.
Sáez, Guillermo T.
Serra-Majem, Lluís 
Muñoz-Bravo, Carlos
Ruiz-Gutiérrez, Valentina
Fiol, Miquel
Vinyoles, Ernest
Pintó, Xavier
Richardson, Kris
Ros, Emilio
Ordovás, Jose M.
Keywords: Cardiovascular Risk-Factors
Target Site Polymorphisms
Type-2 Diabetes-Mellitus
Ischemic-Stroke
Mediterranean Population, et al
Issue Date: 2014
Publisher: 0002-9165
Journal: The American journal of clinical nutrition 
Abstract: Background: MicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). Using an observational meta-analysis design, we previously characterized a gain-of-function microRNA-410 target site polymorphism (rs13702T>C) in the 3' untranslated region of the lipoprotein lipase (LPL) gene. The C allele was associated with lower triglycerides, and this association was modulated by fat intake.Objectives: We aimed to extend our findings by assessing the interaction between the rs13702 polymorphism and fat intake on triglycerides at baseline and longitudinally by using a dietary intervention design. We also examined as a primary outcome the association of this variant with CVD incidence and its modulation by the Mediterranean diet (MedDiet).Design: We studied 7187 participants in the PREDIMED (Prevencion con Dieta Mediterranea) randomized trial that tested a MedDiet intervention compared with a control diet, with a median 4.8-y follow-up. LPL polymorphisms and triglycerides were determined and CVD assessed. Gene-diet interactions for triglycerides were analyzed at baseline (n = 6880) and after a 3-y intervention (n = 4131). Oxidative stress parameters were investigated in a subsample.Results: The rs13702T>C polymorphism was strongly associated with lower triglycerides in C allele carriers and interacted synergistically with dietary monounsaturated (P = 0.038) and unsaturated fat intake (P = 0.037), decreasing triglycerides at baseline. By 3 y, we observed a gene-diet interaction (P = 0.025) in which the C allele was associated with a greater reduction in triglycerides after intervention with MedDiet, high in unsaturated fat. Although the polymorphism was associated with lower stroke risk (HR: 0.74; 95% CI: 0.57, 0.97; P = 0.029 per C allele), this association reached statistical significance only in the MedDiet intervention (HR: 0.58; 95% CI: 0.37, 0.91; P = 0.019 in C compared with TT carriers), not in the control group (HR: 0.94; 95% CI: 0.55, 1.59; P = 0.805).Conclusion: We report a novel association between a microRNA target site variant and stroke incidence, which is modulated by diet in terms of decreasing triglycerides and possibly stroke risk in rs13702 C allele carriers after a high-unsaturated fat MedDiet intervention.
URI: http://hdl.handle.net/10553/44661
ISSN: 0002-9165
DOI: 10.3945/ajcn.113.076992
Source: American Journal of Clinical Nutrition[ISSN 0002-9165],v. 100, p. 719-731
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

41
checked on Nov 17, 2024

WEB OF SCIENCETM
Citations

34
checked on Nov 17, 2024

Page view(s)

33
checked on Dec 10, 2022

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.