Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44661
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dc.contributor.authorCorella, Dolores
dc.contributor.authorSorlí, Jose V.
dc.contributor.authorEstruch, Ramon
dc.contributor.authorColtell, Oscar
dc.contributor.authorOrtega-Azorín, Carolina
dc.contributor.authorPortolés, Olga
dc.contributor.authorMartínez-González, Miguel Ángel
dc.contributor.authorBulló, Mónica
dc.contributor.authorFitó, Montserrat
dc.contributor.authorArós, Fernando
dc.contributor.authorLapetra, José
dc.contributor.authorAsensio, Eva M.
dc.contributor.authorSáez, Guillermo T.
dc.contributor.authorSerra-Majem, Lluís
dc.contributor.authorMuñoz-Bravo, Carlos
dc.contributor.authorRuiz-Gutiérrez, Valentina
dc.contributor.authorFiol, Miquel
dc.contributor.authorVinyoles, Ernest
dc.contributor.authorPintó, Xavier
dc.contributor.authorRichardson, Kris
dc.contributor.authorRos, Emilio
dc.contributor.authorOrdovás, Jose M.
dc.date.accessioned2018-11-22T01:27:20Z-
dc.date.available2018-11-22T01:27:20Z-
dc.date.issued2014
dc.identifier.issn0002-9165
dc.identifier.urihttp://hdl.handle.net/10553/44661-
dc.description.abstractBackground: MicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). Using an observational meta-analysis design, we previously characterized a gain-of-function microRNA-410 target site polymorphism (rs13702T>C) in the 3' untranslated region of the lipoprotein lipase (LPL) gene. The C allele was associated with lower triglycerides, and this association was modulated by fat intake.Objectives: We aimed to extend our findings by assessing the interaction between the rs13702 polymorphism and fat intake on triglycerides at baseline and longitudinally by using a dietary intervention design. We also examined as a primary outcome the association of this variant with CVD incidence and its modulation by the Mediterranean diet (MedDiet).Design: We studied 7187 participants in the PREDIMED (Prevencion con Dieta Mediterranea) randomized trial that tested a MedDiet intervention compared with a control diet, with a median 4.8-y follow-up. LPL polymorphisms and triglycerides were determined and CVD assessed. Gene-diet interactions for triglycerides were analyzed at baseline (n = 6880) and after a 3-y intervention (n = 4131). Oxidative stress parameters were investigated in a subsample.Results: The rs13702T>C polymorphism was strongly associated with lower triglycerides in C allele carriers and interacted synergistically with dietary monounsaturated (P = 0.038) and unsaturated fat intake (P = 0.037), decreasing triglycerides at baseline. By 3 y, we observed a gene-diet interaction (P = 0.025) in which the C allele was associated with a greater reduction in triglycerides after intervention with MedDiet, high in unsaturated fat. Although the polymorphism was associated with lower stroke risk (HR: 0.74; 95% CI: 0.57, 0.97; P = 0.029 per C allele), this association reached statistical significance only in the MedDiet intervention (HR: 0.58; 95% CI: 0.37, 0.91; P = 0.019 in C compared with TT carriers), not in the control group (HR: 0.94; 95% CI: 0.55, 1.59; P = 0.805).Conclusion: We report a novel association between a microRNA target site variant and stroke incidence, which is modulated by diet in terms of decreasing triglycerides and possibly stroke risk in rs13702 C allele carriers after a high-unsaturated fat MedDiet intervention.
dc.publisher0002-9165
dc.relation.ispartofThe American journal of clinical nutrition
dc.sourceAmerican Journal of Clinical Nutrition[ISSN 0002-9165],v. 100, p. 719-731
dc.subject.otherCardiovascular Risk-Factors
dc.subject.otherTarget Site Polymorphisms
dc.subject.otherType-2 Diabetes-Mellitus
dc.subject.otherIschemic-Stroke
dc.subject.otherMediterranean Population
dc.subject.otherFunctional Polymorphism
dc.subject.otherPlasma Triglycerides
dc.subject.otherLipid Concentrations
dc.subject.otherGene Polymorphisms
dc.subject.otherLife-Style
dc.titleMicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.3945/ajcn.113.076992
dc.identifier.scopus84905372264-
dc.identifier.isi000339599100025
dc.contributor.authorscopusid7003570538
dc.contributor.authorscopusid7004605575
dc.contributor.authorscopusid7005989830
dc.contributor.authorscopusid6603090571
dc.contributor.authorscopusid21835135600
dc.contributor.authorscopusid6603006074
dc.contributor.authorscopusid7004290629
dc.contributor.authorscopusid6602243634
dc.contributor.authorscopusid57208853460
dc.contributor.authorscopusid6602891390
dc.contributor.authorscopusid7004158382
dc.contributor.authorscopusid6507771144
dc.contributor.authorscopusid50261129400
dc.contributor.authorscopusid7005090846
dc.contributor.authorscopusid35596972100
dc.contributor.authorscopusid35201757300
dc.contributor.authorscopusid7004979765
dc.contributor.authorscopusid7005315313
dc.contributor.authorscopusid6701665983
dc.contributor.authorscopusid7004430064
dc.contributor.authorscopusid56120329600
dc.contributor.authorscopusid35474202600
dc.contributor.authorscopusid7101791147
dc.description.lastpage731
dc.description.firstpage719
dc.relation.volume100
dc.type2Artículoes
dc.contributor.daisngid25404
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dc.contributor.daisngid1700852
dc.contributor.daisngid23007
dc.contributor.daisngid1564
dc.contributor.wosstandardWOS:Corella, D
dc.contributor.wosstandardWOS:Sorli, JV
dc.contributor.wosstandardWOS:Estruch, R
dc.contributor.wosstandardWOS:Coltell, O
dc.contributor.wosstandardWOS:Ortega-Azorin, C
dc.contributor.wosstandardWOS:Portoles, O
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA
dc.contributor.wosstandardWOS:Bullo, M
dc.contributor.wosstandardWOS:Fito, M
dc.contributor.wosstandardWOS:Aros, F
dc.contributor.wosstandardWOS:Lapetra, J
dc.contributor.wosstandardWOS:Asensio, EM
dc.contributor.wosstandardWOS:Saez, GT
dc.contributor.wosstandardWOS:Serra-Majem, L
dc.contributor.wosstandardWOS:Munoz-Bravo, C
dc.contributor.wosstandardWOS:Ruiz-Gutierrez, V
dc.contributor.wosstandardWOS:Fiol, M
dc.contributor.wosstandardWOS:Vinyoles, E
dc.contributor.wosstandardWOS:Pinto, X
dc.contributor.wosstandardWOS:Richardson, K
dc.contributor.wosstandardWOS:Ros, E
dc.contributor.wosstandardWOS:Ordovas, JM
dc.date.coverdateEnero 2014
dc.identifier.ulpgces
dc.description.sjr3,799
dc.description.jcr6,77
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
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