Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/44651
Campo DC Valoridioma
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorSorlí, Jose V.en_US
dc.contributor.authorGonzález, José I.en_US
dc.contributor.authorOrtega, Carolinaen_US
dc.contributor.authorFitó, Montserraten_US
dc.contributor.authorBulló, Monicaen_US
dc.contributor.authorMartínez-González, Miguel A.en_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorArós, Fernandoen_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorGómez-Gracia, Enriqueen_US
dc.contributor.authorSerra-Majem, Lluísen_US
dc.contributor.authorRuiz-Gutierrez, Valentinaen_US
dc.contributor.authorFiol, Miquelen_US
dc.contributor.authorColtell, Oscaren_US
dc.contributor.authorVinyoles, Ernesten_US
dc.contributor.authorPintó, Xavieren_US
dc.contributor.authorMartí, Ameliaen_US
dc.contributor.authorSaiz, Carmenen_US
dc.contributor.authorOrdovás, José M.en_US
dc.contributor.authorEstruch, Ramónen_US
dc.date.accessioned2018-11-22T01:22:34Z-
dc.date.available2018-11-22T01:22:34Z-
dc.date.issued2014en_US
dc.identifier.issn1475-2840en_US
dc.identifier.otherWoS-
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/44651-
dc.description.abstractBackground: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain.Methods: We analyzed the association between the FAIM2-rs7138803 polymorphism and obesity, blood pressure and heart rate in 7,161 participants (48.3% with type 2 diabetes) in the PREDIMED study at baseline. We also explored gene-diet interactions with adherence to the Mediterranean diet (MedDiet) and examined the effects of the polymorphism on cardiovascular disease incidence per diabetes status after a median 4.8-year dietary intervention (MedDiet versus control group) follow-up.Results: We replicated the association between the FAIM2-rs7138803 polymorphism and greater obesity risk (OR: 1.08; 95% CI: 1.01-1.16; P = 0.011; per-A allele). Moreover, we detected novel associations of this polymorphism with higher diastolic blood pressure (DBP) and heart rate at baseline (B = 1.07; 95% CI: 0.97-1.28 bmp in AA vs G-carriers for the whole population), that remained statistically significant even after adjustment for body mass index (P = 0.012) and correction for multiple comparisons. This association was greater and statistically significant in type-2 diabetic subjects (B = 1.44: 95% CI: 0.23-2.56 bmp; P = 0.010 for AA versus G-carriers). Likewise, these findings were also observed longitudinally over 5-year follow-up. Nevertheless, we found no statistically significant gene-diet interactions with MedDiet for this trait. On analyzing myocardial infarction risk, we detected a nominally significant (P = 0.041) association in type-2 diabetic subjects (HR: 1.86; 95% CI: 1.03-3.37 for AA versus G-carriers), although this association did not remain statistically significant following correction for multiple comparisons.Conclusions: We confirmed the FAIM2-rs7138803 relationship with obesity and identified novel and consistent associations with heart rate in particular in type 2 diabetic subjects. Furthermore, our results suggest a possible association of this polymorphism with higher myocardial infarction risk in type-2 diabetic subjects, although this result needs to be replicated as it could represent a false positive.en_US
dc.languageengen_US
dc.relationPreparacion de la Guia Para la Reduccion de los Desperdicios Alimentarios-Documento Ciber Obn, Fin y Nsfen_US
dc.relationRed Alimentación Saludable en la Prevención Primaria de Enfermedades Crónicas: la Red Predimed. (Retics 2006)en_US
dc.relation.ispartofCardiovascular Diabetologyen_US
dc.sourceCardiovascular Diabetology [EISSN 1475-2840], v. 13, article number 5, (Enero 2014)en_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherBody-Mass Indexen_US
dc.subject.otherGenome-Wide Associationen_US
dc.subject.otherCoronary-Artery-Diseaseen_US
dc.subject.otherCardiovascular-Diseaseen_US
dc.subject.otherMediterranean Dieten_US
dc.subject.otherHeart Rateen_US
dc.subject.otherFAIM2en_US
dc.subject.otherApoptosisen_US
dc.titleNovel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trialen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1475-2840-13-5en_US
dc.identifier.scopus2-s2.0-84891538287-
dc.identifier.scopus84891538287-
dc.identifier.isi000332954300001-
dc.contributor.authorscopusid7003570538-
dc.contributor.authorscopusid7004605575-
dc.contributor.authorscopusid57192590236-
dc.contributor.authorscopusid57190090267-
dc.contributor.authorscopusid6602891390-
dc.contributor.authorscopusid6602243634-
dc.contributor.authorscopusid7004290629-
dc.contributor.authorscopusid35474202600-
dc.contributor.authorscopusid7004158382-
dc.contributor.authorscopusid6507771144-
dc.contributor.authorscopusid57202571697-
dc.contributor.authorscopusid35596972100-
dc.contributor.authorscopusid7004979765-
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dc.contributor.authorscopusid6603090571-
dc.contributor.authorscopusid6701665983-
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dc.contributor.authorscopusid7102814881-
dc.contributor.authorscopusid6602702155-
dc.contributor.authorscopusid7101791147-
dc.contributor.authorscopusid7005989830-
dc.contributor.authorscopusid57208853460-
dc.identifier.eissn1475-2840-
dc.identifier.issue5-
dc.relation.volume13en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid25404-
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dc.description.numberofpages13en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Corella, D-
dc.contributor.wosstandardWOS:Sorli, JV-
dc.contributor.wosstandardWOS:Gonzlez, JI-
dc.contributor.wosstandardWOS:Ortega, C-
dc.contributor.wosstandardWOS:Fit, M-
dc.contributor.wosstandardWOS:Bull, M-
dc.contributor.wosstandardWOS:Martinez-Gonzlez, MA-
dc.contributor.wosstandardWOS:Ros, E-
dc.contributor.wosstandardWOS:Ars, F-
dc.contributor.wosstandardWOS:Lapetra, J-
dc.contributor.wosstandardWOS:Gmez-Gracia, E-
dc.contributor.wosstandardWOS:Serra-Majem, L-
dc.contributor.wosstandardWOS:Ruiz-Gutierrez, V-
dc.contributor.wosstandardWOS:Fiol, M-
dc.contributor.wosstandardWOS:Coltell, O-
dc.contributor.wosstandardWOS:Vinyoles, E-
dc.contributor.wosstandardWOS:Pinto, X-
dc.contributor.wosstandardWOS:Marti, A-
dc.contributor.wosstandardWOS:Saiz, C-
dc.contributor.wosstandardWOS:Ordovs, JM-
dc.contributor.wosstandardWOS:Estruch, R-
dc.date.coverdateEnero 2014en_US
dc.identifier.ulpgces
dc.description.sjr1,58
dc.description.jcr4,015
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
crisitem.project.principalinvestigatorSerra Majem, Luis-
crisitem.project.principalinvestigatorSerra Majem, Luis-
Colección:Artículos
miniatura
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