Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/44651
Campo DC | Valor | idioma |
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dc.contributor.author | Corella, Dolores | en_US |
dc.contributor.author | Sorlí, Jose V. | en_US |
dc.contributor.author | González, José I. | en_US |
dc.contributor.author | Ortega, Carolina | en_US |
dc.contributor.author | Fitó, Montserrat | en_US |
dc.contributor.author | Bulló, Monica | en_US |
dc.contributor.author | Martínez-González, Miguel A. | en_US |
dc.contributor.author | Ros, Emilio | en_US |
dc.contributor.author | Arós, Fernando | en_US |
dc.contributor.author | Lapetra, José | en_US |
dc.contributor.author | Gómez-Gracia, Enrique | en_US |
dc.contributor.author | Serra-Majem, Lluís | en_US |
dc.contributor.author | Ruiz-Gutierrez, Valentina | en_US |
dc.contributor.author | Fiol, Miquel | en_US |
dc.contributor.author | Coltell, Oscar | en_US |
dc.contributor.author | Vinyoles, Ernest | en_US |
dc.contributor.author | Pintó, Xavier | en_US |
dc.contributor.author | Martí, Amelia | en_US |
dc.contributor.author | Saiz, Carmen | en_US |
dc.contributor.author | Ordovás, José M. | en_US |
dc.contributor.author | Estruch, Ramón | en_US |
dc.date.accessioned | 2018-11-22T01:22:34Z | - |
dc.date.available | 2018-11-22T01:22:34Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.issn | 1475-2840 | en_US |
dc.identifier.other | WoS | - |
dc.identifier.other | Scopus | - |
dc.identifier.uri | http://hdl.handle.net/10553/44651 | - |
dc.description.abstract | Background: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain.Methods: We analyzed the association between the FAIM2-rs7138803 polymorphism and obesity, blood pressure and heart rate in 7,161 participants (48.3% with type 2 diabetes) in the PREDIMED study at baseline. We also explored gene-diet interactions with adherence to the Mediterranean diet (MedDiet) and examined the effects of the polymorphism on cardiovascular disease incidence per diabetes status after a median 4.8-year dietary intervention (MedDiet versus control group) follow-up.Results: We replicated the association between the FAIM2-rs7138803 polymorphism and greater obesity risk (OR: 1.08; 95% CI: 1.01-1.16; P = 0.011; per-A allele). Moreover, we detected novel associations of this polymorphism with higher diastolic blood pressure (DBP) and heart rate at baseline (B = 1.07; 95% CI: 0.97-1.28 bmp in AA vs G-carriers for the whole population), that remained statistically significant even after adjustment for body mass index (P = 0.012) and correction for multiple comparisons. This association was greater and statistically significant in type-2 diabetic subjects (B = 1.44: 95% CI: 0.23-2.56 bmp; P = 0.010 for AA versus G-carriers). Likewise, these findings were also observed longitudinally over 5-year follow-up. Nevertheless, we found no statistically significant gene-diet interactions with MedDiet for this trait. On analyzing myocardial infarction risk, we detected a nominally significant (P = 0.041) association in type-2 diabetic subjects (HR: 1.86; 95% CI: 1.03-3.37 for AA versus G-carriers), although this association did not remain statistically significant following correction for multiple comparisons.Conclusions: We confirmed the FAIM2-rs7138803 relationship with obesity and identified novel and consistent associations with heart rate in particular in type 2 diabetic subjects. Furthermore, our results suggest a possible association of this polymorphism with higher myocardial infarction risk in type-2 diabetic subjects, although this result needs to be replicated as it could represent a false positive. | en_US |
dc.language | eng | en_US |
dc.relation | Preparacion de la Guia Para la Reduccion de los Desperdicios Alimentarios-Documento Ciber Obn, Fin y Nsf | en_US |
dc.relation | Red Alimentación Saludable en la Prevención Primaria de Enfermedades Crónicas: la Red Predimed. (Retics 2006) | en_US |
dc.relation.ispartof | Cardiovascular Diabetology | en_US |
dc.source | Cardiovascular Diabetology [EISSN 1475-2840], v. 13, article number 5, (Enero 2014) | en_US |
dc.subject | 3206 Ciencias de la nutrición | en_US |
dc.subject.other | Body-Mass Index | en_US |
dc.subject.other | Genome-Wide Association | en_US |
dc.subject.other | Coronary-Artery-Disease | en_US |
dc.subject.other | Cardiovascular-Disease | en_US |
dc.subject.other | Mediterranean Diet | en_US |
dc.subject.other | Heart Rate | en_US |
dc.subject.other | FAIM2 | en_US |
dc.subject.other | Apoptosis | en_US |
dc.title | Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1186/1475-2840-13-5 | en_US |
dc.identifier.scopus | 2-s2.0-84891538287 | - |
dc.identifier.scopus | 84891538287 | - |
dc.identifier.isi | 000332954300001 | - |
dc.contributor.authorscopusid | 7003570538 | - |
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dc.contributor.authorscopusid | 7005315313 | - |
dc.contributor.authorscopusid | 6603090571 | - |
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dc.contributor.authorscopusid | 7004430064 | - |
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dc.contributor.authorscopusid | 6602702155 | - |
dc.contributor.authorscopusid | 7101791147 | - |
dc.contributor.authorscopusid | 7005989830 | - |
dc.contributor.authorscopusid | 57208853460 | - |
dc.identifier.eissn | 1475-2840 | - |
dc.identifier.issue | 5 | - |
dc.relation.volume | 13 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.contributor.daisngid | 25404 | - |
dc.contributor.daisngid | 495748 | - |
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dc.contributor.daisngid | 16915695 | - |
dc.description.numberofpages | 13 | en_US |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Corella, D | - |
dc.contributor.wosstandard | WOS:Sorli, JV | - |
dc.contributor.wosstandard | WOS:Gonzlez, JI | - |
dc.contributor.wosstandard | WOS:Ortega, C | - |
dc.contributor.wosstandard | WOS:Fit, M | - |
dc.contributor.wosstandard | WOS:Bull, M | - |
dc.contributor.wosstandard | WOS:Martinez-Gonzlez, MA | - |
dc.contributor.wosstandard | WOS:Ros, E | - |
dc.contributor.wosstandard | WOS:Ars, F | - |
dc.contributor.wosstandard | WOS:Lapetra, J | - |
dc.contributor.wosstandard | WOS:Gmez-Gracia, E | - |
dc.contributor.wosstandard | WOS:Serra-Majem, L | - |
dc.contributor.wosstandard | WOS:Ruiz-Gutierrez, V | - |
dc.contributor.wosstandard | WOS:Fiol, M | - |
dc.contributor.wosstandard | WOS:Coltell, O | - |
dc.contributor.wosstandard | WOS:Vinyoles, E | - |
dc.contributor.wosstandard | WOS:Pinto, X | - |
dc.contributor.wosstandard | WOS:Marti, A | - |
dc.contributor.wosstandard | WOS:Saiz, C | - |
dc.contributor.wosstandard | WOS:Ordovs, JM | - |
dc.contributor.wosstandard | WOS:Estruch, R | - |
dc.date.coverdate | Enero 2014 | en_US |
dc.identifier.ulpgc | Sí | es |
dc.description.sjr | 1,58 | |
dc.description.jcr | 4,015 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
item.grantfulltext | open | - |
item.fulltext | Con texto completo | - |
crisitem.author.dept | GIR IUIBS: Nutrición | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.orcid | 0000-0002-9658-9061 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Serra Majem, Luis | - |
crisitem.project.principalinvestigator | Serra Majem, Luis | - |
crisitem.project.principalinvestigator | Serra Majem, Luis | - |
Colección: | Artículos |
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