Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/44651
Campo DC Valoridioma
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorSorlí, Jose V.en_US
dc.contributor.authorGonzález, José I.en_US
dc.contributor.authorOrtega, Carolinaen_US
dc.contributor.authorFitó, Montserraten_US
dc.contributor.authorBulló, Monicaen_US
dc.contributor.authorMartínez-González, Miguel A.en_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorArós, Fernandoen_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorGómez-Gracia, Enriqueen_US
dc.contributor.authorSerra-Majem, Lluísen_US
dc.contributor.authorRuiz-Gutierrez, Valentinaen_US
dc.contributor.authorFiol, Miquelen_US
dc.contributor.authorColtell, Oscaren_US
dc.contributor.authorVinyoles, Ernesten_US
dc.contributor.authorPintó, Xavieren_US
dc.contributor.authorMartí, Ameliaen_US
dc.contributor.authorSaiz, Carmenen_US
dc.contributor.authorOrdovás, José M.en_US
dc.contributor.authorEstruch, Ramónen_US
dc.date.accessioned2018-11-22T01:22:34Z-
dc.date.available2018-11-22T01:22:34Z-
dc.date.issued2014en_US
dc.identifier.issn1475-2840en_US
dc.identifier.otherWoS-
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/44651-
dc.description.abstractBackground: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain.Methods: We analyzed the association between the FAIM2-rs7138803 polymorphism and obesity, blood pressure and heart rate in 7,161 participants (48.3% with type 2 diabetes) in the PREDIMED study at baseline. We also explored gene-diet interactions with adherence to the Mediterranean diet (MedDiet) and examined the effects of the polymorphism on cardiovascular disease incidence per diabetes status after a median 4.8-year dietary intervention (MedDiet versus control group) follow-up.Results: We replicated the association between the FAIM2-rs7138803 polymorphism and greater obesity risk (OR: 1.08; 95% CI: 1.01-1.16; P = 0.011; per-A allele). Moreover, we detected novel associations of this polymorphism with higher diastolic blood pressure (DBP) and heart rate at baseline (B = 1.07; 95% CI: 0.97-1.28 bmp in AA vs G-carriers for the whole population), that remained statistically significant even after adjustment for body mass index (P = 0.012) and correction for multiple comparisons. This association was greater and statistically significant in type-2 diabetic subjects (B = 1.44: 95% CI: 0.23-2.56 bmp; P = 0.010 for AA versus G-carriers). Likewise, these findings were also observed longitudinally over 5-year follow-up. Nevertheless, we found no statistically significant gene-diet interactions with MedDiet for this trait. On analyzing myocardial infarction risk, we detected a nominally significant (P = 0.041) association in type-2 diabetic subjects (HR: 1.86; 95% CI: 1.03-3.37 for AA versus G-carriers), although this association did not remain statistically significant following correction for multiple comparisons.Conclusions: We confirmed the FAIM2-rs7138803 relationship with obesity and identified novel and consistent associations with heart rate in particular in type 2 diabetic subjects. Furthermore, our results suggest a possible association of this polymorphism with higher myocardial infarction risk in type-2 diabetic subjects, although this result needs to be replicated as it could represent a false positive.en_US
dc.languageengen_US
dc.relationPreparacion de la Guia Para la Reduccion de los Desperdicios Alimentarios-Documento Ciber Obn, Fin y Nsfen_US
dc.relationRed Alimentación Saludable en la Prevención Primaria de Enfermedades Crónicas: la Red Predimed. (Retics 2006)en_US
dc.relation.ispartofCardiovascular Diabetologyen_US
dc.sourceCardiovascular Diabetology [EISSN 1475-2840], v. 13, article number 5, (Enero 2014)en_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherBody-Mass Indexen_US
dc.subject.otherGenome-Wide Associationen_US
dc.subject.otherCoronary-Artery-Diseaseen_US
dc.subject.otherCardiovascular-Diseaseen_US
dc.subject.otherMediterranean Dieten_US
dc.subject.otherHeart Rateen_US
dc.subject.otherFAIM2en_US
dc.subject.otherApoptosisen_US
dc.titleNovel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trialen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1475-2840-13-5en_US
dc.identifier.scopus2-s2.0-84891538287-
dc.identifier.scopus84891538287-
dc.identifier.isi000332954300001-
dc.contributor.authorscopusid7003570538-
dc.contributor.authorscopusid7004605575-
dc.contributor.authorscopusid57192590236-
dc.contributor.authorscopusid57190090267-
dc.contributor.authorscopusid6602891390-
dc.contributor.authorscopusid6602243634-
dc.contributor.authorscopusid7004290629-
dc.contributor.authorscopusid35474202600-
dc.contributor.authorscopusid7004158382-
dc.contributor.authorscopusid6507771144-
dc.contributor.authorscopusid57202571697-
dc.contributor.authorscopusid35596972100-
dc.contributor.authorscopusid7004979765-
dc.contributor.authorscopusid7005315313-
dc.contributor.authorscopusid6603090571-
dc.contributor.authorscopusid6701665983-
dc.contributor.authorscopusid7004430064-
dc.contributor.authorscopusid7102814881-
dc.contributor.authorscopusid6602702155-
dc.contributor.authorscopusid7101791147-
dc.contributor.authorscopusid7005989830-
dc.contributor.authorscopusid57208853460-
dc.identifier.eissn1475-2840-
dc.identifier.issue5-
dc.relation.volume13en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid25404-
dc.contributor.daisngid495748-
dc.contributor.daisngid12329907-
dc.contributor.daisngid1379433-
dc.contributor.daisngid74443-
dc.contributor.daisngid31920761-
dc.contributor.daisngid17754-
dc.contributor.daisngid23007-
dc.contributor.daisngid19391611-
dc.contributor.daisngid246378-
dc.contributor.daisngid19997067-
dc.contributor.daisngid28836-
dc.contributor.daisngid124737-
dc.contributor.daisngid78038-
dc.contributor.daisngid441770-
dc.contributor.daisngid442805-
dc.contributor.daisngid115192-
dc.contributor.daisngid70939-
dc.contributor.daisngid2580852-
dc.contributor.daisngid1564-
dc.contributor.daisngid16915695-
dc.description.numberofpages13en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Corella, D-
dc.contributor.wosstandardWOS:Sorli, JV-
dc.contributor.wosstandardWOS:Gonzlez, JI-
dc.contributor.wosstandardWOS:Ortega, C-
dc.contributor.wosstandardWOS:Fit, M-
dc.contributor.wosstandardWOS:Bull, M-
dc.contributor.wosstandardWOS:Martinez-Gonzlez, MA-
dc.contributor.wosstandardWOS:Ros, E-
dc.contributor.wosstandardWOS:Ars, F-
dc.contributor.wosstandardWOS:Lapetra, J-
dc.contributor.wosstandardWOS:Gmez-Gracia, E-
dc.contributor.wosstandardWOS:Serra-Majem, L-
dc.contributor.wosstandardWOS:Ruiz-Gutierrez, V-
dc.contributor.wosstandardWOS:Fiol, M-
dc.contributor.wosstandardWOS:Coltell, O-
dc.contributor.wosstandardWOS:Vinyoles, E-
dc.contributor.wosstandardWOS:Pinto, X-
dc.contributor.wosstandardWOS:Marti, A-
dc.contributor.wosstandardWOS:Saiz, C-
dc.contributor.wosstandardWOS:Ordovs, JM-
dc.contributor.wosstandardWOS:Estruch, R-
dc.date.coverdateEnero 2014en_US
dc.identifier.ulpgces
dc.description.sjr1,58
dc.description.jcr4,015
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
crisitem.project.principalinvestigatorSerra Majem, Luis-
crisitem.project.principalinvestigatorSerra Majem, Luis-
Colección:Artículos
miniatura
pdf
Adobe PDF (527,63 kB)
Vista resumida

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.