Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/44601
Título: Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial
Autores/as: Yu, Edward
Ruiz-Canela, Miguel
Razquin, Cristina
Guasch-Ferré, Marta
Toledo, Estefania
Wang, Dong D.
Papandreou, Christopher
Dennis, Courtney
Clish, Clary
Liang, Liming
Bullo, Monica
Corella, Dolores
Fitó, Montserrat
Gutiérrez-Bedmar, Mario
Lapetra, José
Estruch, Ramón
Ros, Emilio
Cofán, Montserrat
Arós, Fernando
Romaguera, Dora
Serra-Majem, Lluis 
Sorlí, Jose V.
Salas-Salvadó, Jordi
Hu, Frank B.
Martínez-González, Miguel A.
Clasificación UNESCO: 3206 Ciencias de la nutrición
Palabras clave: Nitric-Oxide
Metabolism
Mechanisms
Glucose
Marker, et al.
Fecha de publicación: 2019
Editor/a: 1462-8902
Publicación seriada: Diabetes, Obesity and Metabolism 
Resumen: The associations between arginine-based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case-cohort design, nested within the PREDIMED trial, to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA] and N-monomethyl-l-arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. The 1-year changes in arginine (adjusted hazard ratio [HR] per SD 0.68, 95% confidence interval [CI] 0.49, 0.95; Q4 vs. Q1 0.46, 95% CI 0.21, 1.04; P trend = 0.02) and arginine/ADMA ratio (adjusted HR per SD 0.73, 95% CI 0.51, 1.04; Q4 vs. Q1 0.52, 95% CI 0.22, 1.25; P trend = 0.04) were associated with a lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine + citrulline) were associated with concurrent 1-year changes in homeostatic model assessment of insulin resistance. Individuals in the low-fat-diet group had a higher risk of T2D for 1-year changes in NMMA than individuals in Mediterranean-diet groups (P interaction = 0.02). We conclude that arginine bioavailability is important in T2D pathophysiology.
URI: http://hdl.handle.net/10553/44601
ISSN: 1462-8902
DOI: 10.1111/dom.13514
Fuente: Diabetes Obesity & Metabolism [ISSN 1462-8902], v. 21 (2), p. 397-401
Colección:Artículos
Vista completa

Citas SCOPUSTM   

17
actualizado el 24-mar-2024

Citas de WEB OF SCIENCETM
Citations

15
actualizado el 25-feb-2024

Visitas

58
actualizado el 09-dic-2023

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.