Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44601
DC FieldValueLanguage
dc.contributor.authorYu, Edwarden_US
dc.contributor.authorRuiz-Canela, Miguelen_US
dc.contributor.authorRazquin, Cristinaen_US
dc.contributor.authorGuasch-Ferré, Martaen_US
dc.contributor.authorToledo, Estefaniaen_US
dc.contributor.authorWang, Dong D.en_US
dc.contributor.authorPapandreou, Christopheren_US
dc.contributor.authorDennis, Courtneyen_US
dc.contributor.authorClish, Claryen_US
dc.contributor.authorLiang, Limingen_US
dc.contributor.authorBullo, Monicaen_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorFitó, Montserraten_US
dc.contributor.authorGutiérrez-Bedmar, Marioen_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorEstruch, Ramónen_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorCofán, Montserraten_US
dc.contributor.authorArós, Fernandoen_US
dc.contributor.authorRomaguera, Doraen_US
dc.contributor.authorSerra-Majem, Lluisen_US
dc.contributor.authorSorlí, Jose V.en_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorHu, Frank B.en_US
dc.contributor.authorMartínez-González, Miguel A.en_US
dc.date.accessioned2018-11-22T00:57:29Z-
dc.date.available2018-11-22T00:57:29Z-
dc.date.issued2019en_US
dc.identifier.issn1462-8902en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/44601-
dc.description.abstractThe associations between arginine-based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case-cohort design, nested within the PREDIMED trial, to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA] and N-monomethyl-l-arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. The 1-year changes in arginine (adjusted hazard ratio [HR] per SD 0.68, 95% confidence interval [CI] 0.49, 0.95; Q4 vs. Q1 0.46, 95% CI 0.21, 1.04; P trend = 0.02) and arginine/ADMA ratio (adjusted HR per SD 0.73, 95% CI 0.51, 1.04; Q4 vs. Q1 0.52, 95% CI 0.22, 1.25; P trend = 0.04) were associated with a lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine + citrulline) were associated with concurrent 1-year changes in homeostatic model assessment of insulin resistance. Individuals in the low-fat-diet group had a higher risk of T2D for 1-year changes in NMMA than individuals in Mediterranean-diet groups (P interaction = 0.02). We conclude that arginine bioavailability is important in T2D pathophysiology.en_US
dc.languageengen_US
dc.publisher1462-8902-
dc.relation.ispartofDiabetes, Obesity and Metabolismen_US
dc.sourceDiabetes Obesity & Metabolism [ISSN 1462-8902], v. 21 (2), p. 397-401en_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherNitric-Oxideen_US
dc.subject.otherMetabolismen_US
dc.subject.otherMechanismsen_US
dc.subject.otherGlucoseen_US
dc.subject.otherMarkeren_US
dc.subject.otherDietsen_US
dc.subject.otherAciden_US
dc.subject.otherCohort Studyen_US
dc.subject.otherDietary Interventionen_US
dc.subject.otherInsulin Resistanceen_US
dc.subject.otherObservational Studyen_US
dc.subject.otherPopulation Study, Type 2 Diabetesen_US
dc.titleChanges in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trialen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/dom.13514en_US
dc.identifier.scopus85054304430-
dc.identifier.isi000455806600026-
dc.contributor.authorscopusid56660312400-
dc.contributor.authorscopusid6603417884-
dc.contributor.authorscopusid13612519200-
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dc.contributor.authorscopusid36470858000-
dc.contributor.authorscopusid57130114700-
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dc.contributor.authorscopusid7202069545-
dc.contributor.authorscopusid57194127916-
dc.contributor.authorscopusid7003570538-
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dc.contributor.authorscopusid6507771144-
dc.contributor.authorscopusid7005989830-
dc.contributor.authorscopusid57202569537-
dc.contributor.authorscopusid6602419864-
dc.contributor.authorscopusid7004158382-
dc.contributor.authorscopusid8161433300-
dc.contributor.authorscopusid57202560799-
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dc.contributor.authorscopusid7004290629-
dc.identifier.eissn1463-1326-
dc.description.lastpage401en_US
dc.identifier.issue2-
dc.description.firstpage397en_US
dc.relation.volume21en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid30357635-
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dc.description.numberofpages5en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Yu, E-
dc.contributor.wosstandardWOS:Ruiz-Canela, M-
dc.contributor.wosstandardWOS:Razquin, C-
dc.contributor.wosstandardWOS:Guasch-Ferre, M-
dc.contributor.wosstandardWOS:Toledo, E-
dc.contributor.wosstandardWOS:Wang, DD-
dc.contributor.wosstandardWOS:Papandreou, C-
dc.contributor.wosstandardWOS:Dennis, C-
dc.contributor.wosstandardWOS:Clish, C-
dc.contributor.wosstandardWOS:Liang, LM-
dc.contributor.wosstandardWOS:Bullo, M-
dc.contributor.wosstandardWOS:Corella, D-
dc.contributor.wosstandardWOS:Fito, M-
dc.contributor.wosstandardWOS:Gutierrez-Bedmar, M-
dc.contributor.wosstandardWOS:Lapetra, J-
dc.contributor.wosstandardWOS:Estruch, R-
dc.contributor.wosstandardWOS:Ros, E-
dc.contributor.wosstandardWOS:Cofan, M-
dc.contributor.wosstandardWOS:Aros, F-
dc.contributor.wosstandardWOS:Romaguera, D-
dc.contributor.wosstandardWOS:Serra-Majem, L-
dc.contributor.wosstandardWOS:Sorli, JV-
dc.contributor.wosstandardWOS:Salas-Salvado, J-
dc.contributor.wosstandardWOS:Hu, FB-
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA-
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr2,497
dc.description.jcr5,9
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
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