Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/44483
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Guerra, Borja | en_US |
dc.contributor.author | Guadalupe Grau, Amelia | en_US |
dc.contributor.author | Fuentes, Teresa | en_US |
dc.contributor.author | Ponce-González, Jesús Gustavo | en_US |
dc.contributor.author | Morales Alamo, David | en_US |
dc.contributor.author | Olmedillas, Hugo | en_US |
dc.contributor.author | Guillén Salgado, José Ángel | en_US |
dc.contributor.author | Santana Rodríguez, Alfredo | en_US |
dc.contributor.author | Calbet, Jose A. L. | en_US |
dc.contributor.other | Guerra, Borja | - |
dc.contributor.other | Calbet, Jose A | - |
dc.contributor.other | Guadalupe-Grau, Amelia | - |
dc.contributor.other | Ponce Gonzalez, Jesus Gustavo | - |
dc.contributor.other | Morales-Alamo, David | - |
dc.contributor.other | Fuentes, Teresa | - |
dc.contributor.other | Olmedillas, Hugo | - |
dc.date.accessioned | 2018-11-21T23:57:02Z | - |
dc.date.available | 2018-11-21T23:57:02Z | - |
dc.date.issued | 2010 | en_US |
dc.identifier.issn | 1439-6319 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/44483 | - |
dc.description.abstract | This study was designed to examine potential in vivo mechanisms of AMP-activated protein kinase (AMPK) phosphorylation inhibition and its downstream signaling consequences during the recovery period after a single bout of sprint exercise. Sprint exercise induces Thr172-AMPK phosphorylation and increased PGC-1α mRNA, by an unknown mechanism. Muscle biopsies were obtained in 15 young healthy men in response to a 30-s sprint exercise (Wingate test) randomly distributed into two groups: the fasting (n = 7, C) and the glucose group (n = 8, G), who ingested 75 g of glucose 1 h before exercising to inhibit AMPKα phosphorylation. Exercise elicited different patterns of Ser221-ACCβ, Ser473-Akt and Thr 642-AS160 phosphorylation, during the recovery period after glucose ingestion. Thirty minutes after the control sprint, Ser485AMPKα 1/Ser491-AMPKα2 phosphorylation was reduced by 33% coinciding with increased Thr172-AMPKα phosphorylation (both, P < 0.05). Glucose abolished the 30-min Thr172-AMPKα phosphorylation. Ser221-ACCβ phosphorylation was elevated immediately following and 30 min after exercise in C and G, implying a dissociation between Thr172-AMPKα and Ser221- ACCβ phosphorylation. Two hours after the sprint, PGC-1α protein expression remained unchanged while SIRT1 (its upstream deacetylase) was increased. Glucose ingestion abolished the SIRT1 response without any significant effect on PGC-1α protein expression. In conclusion, glucose ingestion prior to a sprint exercise profoundly affects Thr172- AMPKα phosphorylation and its downstream signaling during the recovery period. | en_US |
dc.language | eng | en_US |
dc.publisher | 1439-6319 | - |
dc.relation | Mecanismos Fisiológicos y Moleculares de la Reducción de Masa Grasa en Seres Humanos Mediante Ejercicios de Musculación. | en_US |
dc.relation.ispartof | European Journal of Applied Physiology | en_US |
dc.source | European Journal Of Applied Physiology[ISSN 1439-6319],v. 109 (4), p. 731-743 | en_US |
dc.subject | 241106 Fisiología del ejercicio | en_US |
dc.subject.other | Fatigue, Human, Performance, Signaling, Skeletal muscle, Wingate | en_US |
dc.title | SIRT1, AMP-activated protein kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise: Influence of glucose ingestion | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1007/s00421-010-1413-y | en_US |
dc.identifier.scopus | 77954887503 | - |
dc.identifier.isi | 000278683100017 | - |
dcterms.isPartOf | European Journal Of Applied Physiology | - |
dcterms.source | European Journal Of Applied Physiology[ISSN 1439-6319],v. 109 (4), p. 731-743 | - |
dc.contributor.authorscopusid | 7006442271 | - |
dc.contributor.authorscopusid | 25627673000 | - |
dc.contributor.authorscopusid | 16301115800 | - |
dc.contributor.authorscopusid | 25628359100 | - |
dc.contributor.authorscopusid | 35148038500 | - |
dc.contributor.authorscopusid | 23051517000 | - |
dc.contributor.authorscopusid | 35726596300 | - |
dc.contributor.authorscopusid | 57192957894 | - |
dc.contributor.authorscopusid | 55617275900 | - |
dc.contributor.authorscopusid | 7004323423 | - |
dc.description.lastpage | 743 | en_US |
dc.description.firstpage | 731 | en_US |
dc.relation.volume | 109 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000278683100017 | - |
dc.contributor.daisngid | 909211 | - |
dc.contributor.daisngid | 861361 | - |
dc.contributor.daisngid | 1500209 | - |
dc.contributor.daisngid | 7526316 | - |
dc.contributor.daisngid | 1264657 | - |
dc.contributor.daisngid | 1232764 | - |
dc.contributor.daisngid | 954582 | - |
dc.contributor.daisngid | 5734696 | - |
dc.contributor.daisngid | 19198365 | - |
dc.contributor.daisngid | 31470516 | - |
dc.contributor.daisngid | 1230811 | - |
dc.contributor.daisngid | 90295 | - |
dc.identifier.investigatorRID | G-9739-2015 | - |
dc.identifier.investigatorRID | H-6693-2015 | - |
dc.identifier.investigatorRID | H-4961-2016 | - |
dc.identifier.investigatorRID | H-9500-2015 | - |
dc.identifier.investigatorRID | D-2683-2009 | - |
dc.identifier.investigatorRID | K-7227-2014 | - |
dc.identifier.investigatorRID | No ID | - |
dc.contributor.wosstandard | WOS:Guerra, B | - |
dc.contributor.wosstandard | WOS:Guadalupe-Grau, A | - |
dc.contributor.wosstandard | WOS:Fuentes, T | - |
dc.contributor.wosstandard | WOS:Ponce-Gonzalez, JG | - |
dc.contributor.wosstandard | WOS:Morales-Alamo, D | - |
dc.contributor.wosstandard | WOS:Olmedillas, H | - |
dc.contributor.wosstandard | WOS:Guillen-Salgado, J | - |
dc.contributor.wosstandard | WOS:Santana, A | - |
dc.contributor.wosstandard | WOS:Calbet, JAL | - |
dc.date.coverdate | Julio 2010 | en_US |
dc.identifier.ulpgc | Sí | es |
dc.description.jcr | 2,214 | |
dc.description.jcrq | Q2 | |
dc.description.scie | SCIE | |
item.fulltext | Sin texto completo | - |
item.grantfulltext | none | - |
crisitem.project.principalinvestigator | López Calbet, José Antonio | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Educación Física | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Educación Física | - |
crisitem.author.orcid | 0000-0003-4355-5682 | - |
crisitem.author.orcid | 0000-0003-1286-8731 | - |
crisitem.author.orcid | 0000-0001-8463-397X | - |
crisitem.author.orcid | 0000-0003-4220-2471 | - |
crisitem.author.orcid | 000-0002-1075-9948 | - |
crisitem.author.orcid | 0000-0002-9215-6234 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Guerra Hernández, Carlos Borja | - |
crisitem.author.fullName | Guadalupe Grau,Amelia | - |
crisitem.author.fullName | Hernández Delgado, Teresa De Jesús | - |
crisitem.author.fullName | Morales Álamo, David | - |
crisitem.author.fullName | Guillén Salgado, José Ángel | - |
crisitem.author.fullName | Santana Rodríguez, Alfredo | - |
crisitem.author.fullName | López Calbet, José Antonio | - |
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