Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/44468
Título: Superior intrinsic mitochondrial respiration in women than in men
Autores/as: Cardinale, Daniele A.
Larsen, Filip J.
Schiffer, Tomas A.
Morales-Alamo, David 
Ekblom, Björn
Boushel, Robert
López Calbet, José Antonio 
Holmberg, Hans-Christer
Clasificación UNESCO: 241110 Fisiología del músculo
Palabras clave: Sexual dimorphism
Mitochondria
Endurance performance
Mitochondrial function
Skeletal muscle, et al.
Fecha de publicación: 2018
Editor/a: 1664-042X
Publicación seriada: Frontiers in Physiology 
Resumen: Sexual dimorphism is apparent in humans, however, to date no studies have investigated mitochondria! function focusing on intrinsic mitochondrial respiration (i.e., mitochondrial respiration for a given amount of mitochondrial protein) and mitochondrial oxygen affinity (p50(mito)) in relation to biological sex in human. A skeletal muscle biopsy was donated by nine active women, and ten men matched for maximal oxygen consumption (VO2max) and by nine endurance trained men. Intrinsic mitochondrial respiration, assessed in isolated mitochondria, was higher in women compared to men when activating complex I (Cl-p) and complex I+II(Cl+IIp) (p < 0.05), and was similar to trained men (Cl-p, p = 0.053; Cl+IIp, p = 0.066). Proton leak and p50(mito) to were higher in women compared to men independent of VO2max. In conclusion, significant novel differences in mitochondrial oxidative function, intrinsic mitochondrial respiration and p50(mito) to exist between women and men. These findings may represent an adaptation in the oxygen cascade in women to optimize muscle oxygen uptake to compensate for a lower oxygen delivery during exercise.
URI: http://hdl.handle.net/10553/42168
ISSN: 1664-042X
DOI: 10.3389/fphys.2018.01133
Fuente: Frontiers in Physiology [ISSN 1664-042X], v. 9, article number 1133
Colección:Artículos
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