Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44460
Title: GABAA and GABAB receptors are functionally active in the regulation of catecholamine secretion by bovine chromaffin cells
Authors: Castro López-Tarruella, Enrique 
Oset‐Gasque, M. J.
González, M. P.
UNESCO Clasification: 240104 Citología animal
241003 Citología humana
320502 Endocrinología
Keywords: GABA receptor
Catecholamine secretion
Chromaffin cell
Issue Date: 1989
Publisher: 0360-4012
Journal: Journal of Neuroscience Research 
Abstract: GABA stimulates the basal catecholamine release from adrenal bovine chromaffin cells in a calciumdependent manner. This release represents about 70% of that obtained by similar doses of nicotine under similar experimental conditions. This effect is mediated by GABAA receptor sites present in chromaffin cells, since it was mimicked by muscimol and reversed by bicuculline. In addition, GABA, through its GABAA receptors, increases the catecholamine release evoked by submaximal doses of aicotine, but it has no effect on nicotine‐evoked secretion of catecholamines when nicotine was given at maximal doses. These results seem to indicate that both nicotine and GABA release catecholamines from the same intracellular pool. In contrast, baclofen, a GABAB receptor agonist, depressed both basal and nicotineevoked catecholamine release; this result indicates that in addition to GABAA control of catecholamine secretion by chromaffin cells, there is a GABAB control of this function. These results support the existence of a dual regulation of catecholamine secretion by both the GABAA and GABAB receptors in a similar way as that proposed for muscarinic and nicotinic cholinergic receptors.
URI: http://hdl.handle.net/10553/44460
ISSN: 0360-4012
DOI: 10.1002/jnr.490230307
Source: Journal of Neuroscience Research [ISSN 0360-4012], v. 23, p. 290-296
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