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Title: Effect of diadenosine polyphosphates on catecholamine secretion from isolated chromaffin cells
Authors: Castro López-Tarruella, Enrique 
Torres, M.
Miras-Portugal, M. T.
Gonzalez, M. P.
UNESCO Clasification: 32 Ciencias médicas
Issue Date: 1990
Publisher: 0007-1188
Journal: British journal of pharmacology 
Abstract: The action of several diadenosine polyphosphates (AP3A, AP4A and AP5A) on basal, and on nicotine‐and high K+‐evoked, catecholamine (CA) release has been investigated. Each of the three diadenosine polyphosphates weakly but significantly increased basal CA secretion. This enhancement represented about 10% of the response evoked by 2 μm nicotine. The evoked secretory response to diadenosine polyphosphates had an absolute requirement for extracellular Ca2+. In contrast, these compounds had an inhibitory action on nicotine‐evoked release. This response was concentration‐dependent, EC50 values being 3.2 ± 0.4 μm, 4.0 ± 1.6 μm and 19.3 ± 4.0 μm for AP3A, AP4A, and AP5A, respectively. The lower the concentration of nicotine used to evoke secretion, the higher the inhibitory power of these compounds. The CA secretion evoked by K+‐rich solutions was further enhanced by AP3A and AP5A, whereas AP4A inhibited it. The possible physiological role of these dual actions is discussed.
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1990.tb15809.x
Source: British Journal of Pharmacology [ISSN 0007-1188], v. 100, p. 360-364
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