Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/44446
Campo DC Valoridioma
dc.contributor.authorHerrero, I.en_US
dc.contributor.authorCastro López-Tarruella, Enriqueen_US
dc.contributor.authorMiras-Portugal, M. T.en_US
dc.contributor.authorSánchez-Prieto, J.en_US
dc.date.accessioned2018-11-21T23:08:34Z-
dc.date.available2018-11-21T23:08:34Z-
dc.date.issued1996en_US
dc.identifier.issn0022-3042en_US
dc.identifier.urihttp://hdl.handle.net/10553/44446-
dc.description.abstractThe total Ca(2+)-dependent release of glutamate induced by depolarization of cerebrocortical nerve terminals with KCl was analyzed into a fast and a slow component. The fast component exhibited a decay time of < 1 s and accounted for 0.95 +/- 0.10 nmol of glutamate, whereas the slow component, which exhibited a decay time of 52 +/- 7 s, accounted for the release of 2.48 +/- 0.19 nmol of glutamate. These two components were differentially affected by the Ca2+ chelator BAPTA, the divalent cation Sr2+, or the botulinum neurotoxin A. The adenosine A1 receptor agonist N6-cyclohexyladenosine strongly reduced the fast component without altering the slow component. In contrast, the inhibitory effect of arachidonic acid and the facilitatory action of the metabotropic glutamate receptor agonist (1S, 3R)-1-aminocyclopentane-1, 3-dicarboxylic acid were observed as a decrease and an increase, respectively, in the two components. It is concluded, first, that the fast and slow components correspond to the release of docked and mobilized vesicles, respectively, and second, that presynaptic modulation more significantly alters the fast component of release.en_US
dc.languageengen_US
dc.publisher0022-3042-
dc.relation.ispartofJournal of Neurochemistryen_US
dc.sourceJournal of Neurochemistry [ISSN 0022-3042], v. 67, p. 2346-2354en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherExocytosisen_US
dc.subject.otherGlutamate releaseen_US
dc.subject.otherStrontium ionen_US
dc.subject.otherBAPTAen_US
dc.subject.otherBotulinum neurotoxin Aen_US
dc.subject.otherPresynaptic modulationen_US
dc.subject.otherRelease componentsen_US
dc.titleTwo components of glutamate exocytosis differentially affected by presynaptic modulationen_US
dc.typeinfo:eu-repo/semantics/articlees
dc.typeArticlees
dc.identifier.scopus0029824033-
dc.contributor.authorscopusid8061162100-
dc.contributor.authorscopusid35095882100-
dc.contributor.authorscopusid24528882700-
dc.contributor.authorscopusid7005495388-
dc.description.lastpage2354-
dc.description.firstpage2346-
dc.relation.volume67-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.ulpgces
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.fullNameCastro López-Tarruella, Enrique-
Colección:Artículos
Vista resumida

Google ScholarTM

Verifica


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.