Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44436
DC FieldValueLanguage
dc.contributor.authorMiras-Portugal, M. Teresaen_US
dc.contributor.authorDíaz-Hernández, Miguelen_US
dc.contributor.authorGomez-Villafuerte, Rosaen_US
dc.contributor.authorGualix, Javieren_US
dc.contributor.authorCastro López-Tarruella, Enriqueen_US
dc.contributor.authorPintor, Jesúsen_US
dc.date.accessioned2018-11-21T23:03:59Z-
dc.date.available2018-11-21T23:03:59Z-
dc.date.issued2000en_US
dc.identifier.issn0165-1838en_US
dc.identifier.urihttp://hdl.handle.net/10553/44436-
dc.description.abstractSynaptosomal preparations from rat midbrain exhibit specific responses to both ATP and Ap5A, which elicit a Ca2+ entrance to the presynaptic terminals. Studies of isolated single terminals showed that not all the terminals contain ionotropic receptors for nucleotides, in fact only 46% of them do. Of these, 12% responded only to the dinucleotide Ap5A, and 20% to the mononucleotide ATP. At the presynaptic level, diinosine pentaphosphate, Ip5I, is a good tool to specifically block dinucleotide responses, which are inhibited at low nM concentration, versus the high μM concentrations required to block ATP responses. There is evidence for a presynaptic control of mononucleotide and dinucleotide responses, mediated by metabotropic and ionotropic receptors. Stimulation of adenosine A1 receptors increases the affinity of dinucleotide receptors by five orders of magnitude, from 30 μM to 680 pM for control and in the presence of A1 agonist, respectively.en_US
dc.languageengen_US
dc.publisher0165-1838-
dc.relation.ispartofJournal of the Autonomic Nervous Systemen_US
dc.sourceJournal of the Autonomic Nervous System [ISSN 0165-1838], v. 81, p. 195-199en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherNucleotideen_US
dc.subject.otherDiadenosine polyphosphatesen_US
dc.subject.otherDinucleotide receptoren_US
dc.subject.otherDiinosine polyphosphatesen_US
dc.subject.otherAdenosineen_US
dc.titlePresynaptic signalling mediated by mono- and dinucleotides in the central nervous systemen_US
dc.typeinfo:eu-repo/semantics/articlees
dc.typeArticlees
dc.identifier.doi10.1016/S0165-1838(00)00138-7-
dc.identifier.scopus0343953473-
dc.contributor.authorscopusid24528882700-
dc.contributor.authorscopusid6603055162-
dc.contributor.authorscopusid6603084924-
dc.contributor.authorscopusid6701594811-
dc.contributor.authorscopusid35095882100-
dc.contributor.authorscopusid7004412527-
dc.description.lastpage199-
dc.description.firstpage195-
dc.relation.volume81-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.ulpgces
dc.description.jcr1,386
dc.description.jcrqQ3
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.fullNameCastro López-Tarruella, Enrique-
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