Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/44436
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Miras-Portugal, M. Teresa | en_US |
dc.contributor.author | Díaz-Hernández, Miguel | en_US |
dc.contributor.author | Gomez-Villafuerte, Rosa | en_US |
dc.contributor.author | Gualix, Javier | en_US |
dc.contributor.author | Castro López-Tarruella, Enrique | en_US |
dc.contributor.author | Pintor, Jesús | en_US |
dc.date.accessioned | 2018-11-21T23:03:59Z | - |
dc.date.available | 2018-11-21T23:03:59Z | - |
dc.date.issued | 2000 | en_US |
dc.identifier.issn | 0165-1838 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/44436 | - |
dc.description.abstract | Synaptosomal preparations from rat midbrain exhibit specific responses to both ATP and Ap5A, which elicit a Ca2+ entrance to the presynaptic terminals. Studies of isolated single terminals showed that not all the terminals contain ionotropic receptors for nucleotides, in fact only 46% of them do. Of these, 12% responded only to the dinucleotide Ap5A, and 20% to the mononucleotide ATP. At the presynaptic level, diinosine pentaphosphate, Ip5I, is a good tool to specifically block dinucleotide responses, which are inhibited at low nM concentration, versus the high μM concentrations required to block ATP responses. There is evidence for a presynaptic control of mononucleotide and dinucleotide responses, mediated by metabotropic and ionotropic receptors. Stimulation of adenosine A1 receptors increases the affinity of dinucleotide receptors by five orders of magnitude, from 30 μM to 680 pM for control and in the presence of A1 agonist, respectively. | en_US |
dc.language | eng | en_US |
dc.publisher | 0165-1838 | - |
dc.relation.ispartof | Journal of the Autonomic Nervous System | en_US |
dc.source | Journal of the Autonomic Nervous System [ISSN 0165-1838], v. 81, p. 195-199 | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject.other | Nucleotide | en_US |
dc.subject.other | Diadenosine polyphosphates | en_US |
dc.subject.other | Dinucleotide receptor | en_US |
dc.subject.other | Diinosine polyphosphates | en_US |
dc.subject.other | Adenosine | en_US |
dc.title | Presynaptic signalling mediated by mono- and dinucleotides in the central nervous system | en_US |
dc.type | info:eu-repo/semantics/article | es |
dc.type | Article | es |
dc.identifier.doi | 10.1016/S0165-1838(00)00138-7 | - |
dc.identifier.scopus | 0343953473 | - |
dc.contributor.authorscopusid | 24528882700 | - |
dc.contributor.authorscopusid | 6603055162 | - |
dc.contributor.authorscopusid | 6603084924 | - |
dc.contributor.authorscopusid | 6701594811 | - |
dc.contributor.authorscopusid | 35095882100 | - |
dc.contributor.authorscopusid | 7004412527 | - |
dc.description.lastpage | 199 | - |
dc.description.firstpage | 195 | - |
dc.relation.volume | 81 | - |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.ulpgc | Sí | es |
dc.description.jcr | 1,386 | |
dc.description.jcrq | Q3 | |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.fullName | Castro López-Tarruella, Enrique | - |
Appears in Collections: | Artículos |
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