Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/44428
Título: Specific diadenosine pentaphosphate receptor coupled to extracellular regulated kinases in cerebellar astrocytes
Autores/as: Jiménez, Ana I.
Castro López-Tarruella, Enrique 
Delicado, Esmerilda G.
Miras-Portuga, M. Teresa
Clasificación UNESCO: 32 Ciencias médicas
Palabras clave: Astrocytes
Calcium
Dinucleotides
ERK activation
Glia, et al.
Fecha de publicación: 2002
Editor/a: 0022-3042
Publicación seriada: Journal of Neurochemistry 
Resumen: In this study, we show specific intracellular responses evoked by the stimulation of astrocytes with the P1,P5‐di(adenosine‐5′)pentaphosphate, Ap5A. The stimulation of astrocytes with micromolar concentrations of the dinucleotide elicited rapid increases in intracellular calcium concentration ([Ca2+]i), showing an EC50 value of 15.27 ± 0.61 µm. Moreover, the stimulation of cells with nanomolar concentrations of Ap5A, unable to induce calcium responses, increased the phosphorylated forms of extracellular‐signal regulated kinase 1/2 (ERK) with an EC50 value of 9.8 ± 2.4 nm. The maximal activation was observed at 100 nm Ap5A, which was similar to that produced by epidermal growth factor (EGF) under the same experimental conditions. The present data reported here indicate that Ap5A mediated these effects by interacting with a specific receptor, not yet identified, which was different from the P2Y1 and P2Y2/P2Y4 receptors present in all individual astrocytes.
URI: http://hdl.handle.net/10553/44428
ISSN: 0022-3042
DOI: 10.1046/j.1471-4159.2002.01111.x
Fuente: Journal of Neurochemistry [ISSN 0022-3042], v. 83, p. 299-308
Colección:Artículos
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