Please use this identifier to cite or link to this item: https://accedacris.ulpgc.es/handle/10553/44344
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dc.contributor.authorMcNeill, Alisdairen_US
dc.contributor.authorWu, Ruey Meeien_US
dc.contributor.authorTzen, Kai Yuanen_US
dc.contributor.authorAguiar, Patricia C.en_US
dc.contributor.authorArbelo González, José Matíasen_US
dc.contributor.authorBarone, Paoloen_US
dc.contributor.authorBhatia, Kailashen_US
dc.contributor.authorBarsottini, Orlandoen_US
dc.contributor.authorBonifati, Vincenzoen_US
dc.contributor.authorBostantjopoulou, Sevastien_US
dc.contributor.authorBressan, Rodrigoen_US
dc.contributor.authorCossu, Giovannien_US
dc.contributor.authorCortelli, Pietroen_US
dc.contributor.authorFelicio, Andreen_US
dc.contributor.authorFerraz, Henrique B.en_US
dc.contributor.authorHerrera, Joannaen_US
dc.contributor.authorHoulden, Henryen_US
dc.contributor.authorHoexter, Marceloen_US
dc.contributor.authorIsla, Concepcionen_US
dc.contributor.authorLees, Andrewen_US
dc.contributor.authorLorenzo-Betancor, Oswaldoen_US
dc.contributor.authorMencacci, Niccolo E.en_US
dc.contributor.authorPastor, Pauen_US
dc.contributor.authorPappata, Sabinaen_US
dc.contributor.authorPellecchia, Maria Teresaen_US
dc.contributor.authorSilveria-Moriyama, Lauraen_US
dc.contributor.authorVarrone, Andreaen_US
dc.contributor.authorFoltynie, Tomen_US
dc.contributor.authorSchapira, Anthony H.V.en_US
dc.date.accessioned2018-11-21T22:14:16Z-
dc.date.available2018-11-21T22:14:16Z-
dc.date.issued2013en_US
dc.identifier.urihttps://accedacris.ulpgc.es/handle/10553/44344-
dc.description.abstractObjectives: To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease. Methods: A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right:left asymmetry index and striatal asymmetry index was calculated. Results: Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). The asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations. Conclusions: The asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss.en_US
dc.languageengen_US
dc.relation.ispartofPLoS ONEen_US
dc.sourcePLoS ONE,v. 8 (e69190)en_US
dc.subject320507 Neurologíaen_US
dc.titleDopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesisen_US
dc.typeinfo:eu-repo/semantics/articlees
dc.typeArticlees
dc.identifier.doi10.1371/journal.pone.0069190en_US
dc.identifier.scopus2-s2.0-84880707725-
dc.contributor.authorscopusid7005854156-
dc.contributor.authorscopusid7402944843-
dc.contributor.authorscopusid7005128166-
dc.contributor.authorscopusid6602635095-
dc.contributor.authorscopusid26655226900-
dc.contributor.authorscopusid7102266387-
dc.contributor.authorscopusid25958636400-
dc.contributor.authorscopusid55879071800-
dc.contributor.authorscopusid7005955544-
dc.contributor.authorscopusid55977734100-
dc.contributor.authorscopusid7005575041-
dc.contributor.authorscopusid7006464266-
dc.contributor.authorscopusid16439271400-
dc.contributor.authorscopusid55667247400-
dc.contributor.authorscopusid7005610910-
dc.contributor.authorscopusid55804165400-
dc.contributor.authorscopusid7003363686-
dc.contributor.authorscopusid8941895000-
dc.contributor.authorscopusid16241216700-
dc.contributor.authorscopusid23988930400-
dc.contributor.authorscopusid36025528700-
dc.contributor.authorscopusid35176436700-
dc.contributor.authorscopusid56513542800-
dc.contributor.authorscopusid56243181600-
dc.contributor.authorscopusid7007039088-
dc.contributor.authorscopusid55804576500-
dc.contributor.authorscopusid6701713624-
dc.contributor.authorscopusid8984550100-
dc.contributor.authorscopusid7102634392-
dc.identifier.issuee69190-
dc.relation.volume8-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.ulpgces
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.fullNameArbelo González, José Matías-
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