Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/44344
Título: Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis
Autores/as: McNeill, Alisdair
Wu, Ruey Meei
Tzen, Kai Yuan
Aguiar, Patricia C.
Arbelo González, José Matías 
Barone, Paolo
Bhatia, Kailash
Barsottini, Orlando
Bonifati, Vincenzo
Bostantjopoulou, Sevasti
Bressan, Rodrigo
Cossu, Giovanni
Cortelli, Pietro
Felicio, Andre
Ferraz, Henrique B.
Herrera, Joanna
Houlden, Henry
Hoexter, Marcelo
Isla, Concepcion
Lees, Andrew
Lorenzo-Betancor, Oswaldo
Mencacci, Niccolo E.
Pastor, Pau
Pappata, Sabina
Pellecchia, Maria Teresa
Silveria-Moriyama, Laura
Varrone, Andrea
Foltynie, Tom
Schapira, Anthony H.V.
Clasificación UNESCO: 320507 Neurología
Fecha de publicación: 2013
Publicación seriada: PLoS ONE
Resumen: Objectives: To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease. Methods: A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right:left asymmetry index and striatal asymmetry index was calculated. Results: Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). The asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations. Conclusions: The asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss.
URI: http://hdl.handle.net/10553/44344
DOI: 10.1371/journal.pone.0069190
Fuente: PLoS ONE,v. 8 (e69190)
Colección:Artículos
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