Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43880
Title: Dietary alpha-linolenic acid, Marine omega-3 fatty acids, and mortality in a population with high fish consumption: findings from the PREvencion con Dleta MEDiterranea (PREDIMED) Study
Authors: Sala-Vila, Aleix
Guasch-Ferré, Marta
Hu, Frank B.
Sánchez-Tainta, Ana
Bulló, Mònica
Serra-Mir, Mercè
López-Sabater, Carmen
Sorlí, Jose V.
Arós, Fernando
Fiol, Miquel
Muñoz, Miguel A.
Serra Majem, Luis 
Alfredo Martínez, J.
Corella, Dolores
Fitó, Montserrat
Salas-Salvadó, Jordi
Martínez-González, Miguel A.
Estruch, Ramón
Ros, Emilio
Pérez-Heras, A.
Viñas, C.
Casas, R.
De Santamaría, L.
Romero, S.
Sacanella, E.
Chiva, G.
Valderas, P.
Arranz, S.
Baena, J. M.
García, M.
Oller, M.
Amat, J.
Duaso, I.
García, Y.
Iglesias, C.
Simón, C.
Quinzavos, Ll
Parra, Ll
Liroz, M.
Benavent, J.
Clos, J.
Pla, I.
Amorós, M.
Bonet, M. T.
Martin, M. T.
Sánchez, M. S.
Altirriba, J.
Manzano, E.
Altés, A.
Cofán, M.
Valls-Pedret, C.
Doménech, M.
Gilabert, R.
Bargalló, N.
González, R.
Molina, C.
Márquez, F.
Babio, N.
Sorli, M.
García Roselló, J.
Diaz-López, A.
Martin, F.
Tort, R.
Isach, A.
Costa, B.
Cabré, J. J.
Fernández-Ballart, J.
Ibarrola-Jurado, N.
Alegret, C.
Martínez, P.
Millán, S.
Piñol, J. L.
Basora, T.
Hernández, J. M.
Toledo, E.
Buil-Cosiales, P.
Ruiz-Canela, M.
Sanjulián, B.
Díez-Espino, J.
Extremera-Urabayen, V.
García-Arellano, A.
Zazpe, I.
Basterra-Gortari, F. J.
Goñi, E.
Razquin, C.
Serrano-Martínez, M.
Bes-Rastrollo, M.
Gea, A.
Martínez-Lapiscina, E. H.
Nuñez-Córdoba, J. M.
Arroyo-Azpa, C.
García-Pérez, L.
Villanueva-Tellería, J.
Cortés-Ugalde, F.
Sagredo-Arce, T.
De La Noceda-Montoy, Ma D.García
Vigata-López, Ma D.
Arceiz-Campo, Ma T.
Urtasun-Samper, A.
UNESCO Clasification: 32 Ciencias médicas
Keywords: Fatty Acid
Nutrition
Sudden Cardiac Death
Issue Date: 2016
Journal: Journal of the American Heart Association 
Abstract: Background: Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain n‐3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all‐cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long‐chain n‐3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results: We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable‐adjusted Cox regression models were fitted to estimate hazard ratios. ALA intake correlated to walnut consumption (r=0.94). During a 5.9‐y follow‐up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios for meeting ALA recommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56–0.92) for all‐cause mortality and 0.95 (95% CI 0.58–1.57) for fatal cardiovascular disease. The hazard ratios for meeting the recommendation for long‐chain n‐3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67–1.05) for all‐cause mortality, 0.61 (95% CI 0.39–0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29–0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22–1.01) for sudden cardiac death. The highest reduction in all‐cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45–0.87]). Conclusions: In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all‐cause mortality, whereas protection from cardiac mortality is limited to fish‐derived long‐chain n‐3 polyunsaturated fatty acids.
URI: http://hdl.handle.net/10553/43880
ISSN: 2047-9980
DOI: 10.1161/JAHA.115.002543
Source: Journal Of The American Heart Association [ISSN 2047-9980], v. 5 (1), (Enero 2016)
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

49
checked on May 16, 2021

WEB OF SCIENCETM
Citations

43
checked on May 16, 2021

Page view(s)

43
checked on May 16, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.