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Title: A new approach to elastography using a modified demons registration algorithm
Authors: Sosa-Cabrera, Dario
Tristan-Vega, Antonio
Vegas-Sanchez-Ferrero, Gonzalo
Gonzalez-Fernandez, Javier
Gómez Déniz, Luis 
Alberla-Lopez, Carlos
Ruiz-Alzola, Juan 
UNESCO Clasification: 32 Ciencias médicas
Keywords: Breast-Lesions
Issue Date: 2008
Publisher: 1605-7422
Journal: Proceedings of SPIE - The International Society for Optical Engineering 
Conference: Medical Imaging 2008 Conference 
Medical Imaging 2008: Ultrasonic Imaging and Signal Processing 
Abstract: Changes in tissue stiffness correlate with pathological phenomena that can aid the diagnosis of several diseases such as breast and prostate cancer. Ultrasound elastography measures the elastic properties of soft tissues using ultrasound signals. The standard way to estimate the displacement field from which researchers obtain the strain in elastography is the time-domain cross-correlation estimator (TDE). Optical flow (OF) methods have been also characterized and their use keeps increasing. We introduce in this paper the use of a Modified Demons Algorithm (MDA) to estimate the displacement field and we compare it with OF. A least-squares strain estimator (LSE) is applied to estimate the strain from the displacement. The input for the algorithm comes from the ultrasound scanner standard video output; therefore, its clinical implementation is immediate. To test the algorithm, a tissuemimicking phantom was modeled as a 10x10x5 cm region containing a centered 10mm cylindrical inclusion three times stiffer than the surrounding material, and its elastic behavior was simulated using COMSOL Multiphysics 3.2 software. Synthetic pre- and post-compression (1.25%) B-mode images were computer generated using FIELD II ultrasound simulator. Afterward, the algorithm was tested with a commercial CIRS breast elastography phantom, applying a 2% freehand compression. Axial displacement fields and strain figures are presented and in the case of the synthetic one compared to the ground truth given by the FE software. Although other researchers have used registration methods for elastography, as far as we know, they have not been used as stand alone but together with elastic modulus reconstruction or FE which iteratively varies material properties to improve registration.
ISBN: 978-0-8194-7104-8
ISSN: 0277-786X
DOI: 10.1117/12.768789
Source: Medical Imaging 2008: Ultrasonic Imaging And Signal Processing [ISSN 0277-786X], v. 6920
Appears in Collections:Actas de congresos
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