Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/43730
Título: Serum and 24-hour urine analysis in adult cyanotic and noncyanotic congenital heart disease patients
Autores/as: Martínez-Quintana, Efrén 
Rodríguez-González, Fayna
Fábregas-Brouard, Marian
Nieto-Lago, Vicente
Clasificación UNESCO: 320501 Cardiología
Palabras clave: Proteinuria
Microalbuminuria
Impaired renal function
Cyanotic
Congenital heart disease
Fecha de publicación: 2009
Editor/a: 1747-079X
Publicación seriada: Congenital Heart Disease 
Resumen: Introduction. Glomerulopathy is a complication of congenital heart disease patients. The risk of developing renal impairment is particularly high in cyanotic patients. Objective. The aim of this study was to determine the prevalence of renal dysfunction and microalbumiuria in adult cyanotic and non cyanotic congenital heart disease patients. Methods. Fourteen cyanotic and 22 noncyanotic congenital heart disease patients were studied in the Adult Congenital Heart Disease Unit at the Complejo Hospitalario Universitario Insular‐Materno Infantil. Demographic characteristics, complete blood count, and 24‐hour urianalysis were obtained, including abdominal ultrasound in those with cyanosis. Results. No differences were seen between age (years) (27.4 ± 8.2; 26.4 ± 8.3; P = .71), sex, size, weight, or glomerular filtration rate (mL/min/1.73 m2) (81.1 ± 22.9 vs. 84.9 ± 9.2, P = .482) between cyanotic and noncyanotic patients. However, Eisenmenger patients had significantly impaired renal function when compared with noncyanotic patients (73.0 ± 17.3 vs. 84.9 ± 9.2 mL/min/1.73 m2, P = .023). Significant differences were obtained in oxygen saturation (%) (83.8 ± 5.8 vs. 97.8 ± 0.8; P = .000), hematocrit (%) (59.3 ± 8.1 vs. 40.9 ± 8.5; P = .000), platelets (103/µL) (161.5 ± 70.5 vs. 277.9 ± 57.6; P = .000), serum uric acid (mg/dL) (7.5 ± 2.3 vs. 5.6 ± 1.5; P = .008) and microalbuminuria (mg/24 hours) (12.8 [0, 700.2] vs. 2.4 [0, 18.9]; P = .000) between cyanotic and noncyanotic patients. Five cyanotic patients (35.7%) had microalbuminuria (>30 mg/24 hours) and three of them (21.4%) proteinuria (>1 g/24 hours). No significant differences were seen between serum and urine parameters between cyanotic patients who had microalbuminuria (>30 mg/24 hours) and those cyanotic patients who did not have it (<30 mg/24 hours). Conclusions. Renal impairment is frequently seen in congenital heart disease patients, being associated occasionally with proteinuria and microalbuminuria in cyanotic ones.
URI: http://hdl.handle.net/10553/43730
ISSN: 1747-079X
DOI: 10.1111/j.1747-0803.2009.00273.x
Fuente: Congenital Heart Disease [ISSN 1747-079X], v. 4, p. 147-152
Colección:Artículos
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