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Title: Serum uric acid levels and cardiovascular disease: The Gordian knot
Authors: Martínez Quintana, Efrén 
Tugores, Antonio 
Rodríguez-González, Fayna
UNESCO Clasification: 32 Ciencias médicas
Keywords: Hyperuricemia
Cardiovascular risk factors
Coronary artery disease
Mendelian randomization
Issue Date: 2016
Publisher: 2072-1439
Journal: Journal of Thoracic Disease 
Abstract: Hyperuricemia is defined as serum uric acid level of more than 7 mg/dL and blood levels of uric acid are causally associated with gout, as implicated by evidence from randomized clinical trials using urate lowering therapies. Uric acid as a cardiovascular risk factor often accompanies metabolic syndrome, hypertension, diabetes, dyslipidemia, chronic renal disease, and obesity. Despite the association of hyperuricemia with cardiovascular risk factors, it has remained controversial as to whether uric acid is an independent predictor of cardiovascular disease. To settle this issue, and in the absence of large randomized controlled trials, Mendelian randomization analysis in which the exposure is defined based on the presence or absence of a specific allele that influences a risk factor of interest have tried to shed light on this.
ISSN: 2072-1439
DOI: 10.21037/jtd.2016.11.39
Source: Journal of Thoracic Disease [ISSN 2072-1439], v. 8, p. E1462-E1466
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