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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43487
DC FieldValueLanguage
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorBrouard, Ignacioen_US
dc.contributor.authorRivera, Augustoen_US
dc.contributor.authorTorres, Fernandoen_US
dc.contributor.authorRubio Sánchez, Saraen_US
dc.contributor.authorQuintana Aguiar, José Martínen_US
dc.contributor.authorEstévez Rosas, Francisco Jesúsen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.otherQuintana, Jose-
dc.contributor.otherRubio, Sara-
dc.contributor.otherBrouard, Ignacio-
dc.contributor.otherTorres Andon, Fernando-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherLeon, Francisco-
dc.contributor.otherRubio Sánchez, Sara-
dc.date.accessioned2018-11-21T15:33:12Z-
dc.date.available2018-11-21T15:33:12Z-
dc.date.issued2006en_US
dc.identifier.issn0022-2623en_US
dc.identifier.urihttp://hdl.handle.net/10553/43487-
dc.description.abstractTwo new long-chain ceramides, trametenamides A (1) and B (2), were isolated from the methanolic extract of the fruiting body of the fungus Trametes menziesii. The structures were elucidated by spectroscopic analyses and chemical transformations, and the absolute stereochemistry of trametenamide B (2) was determined by stereoselective total synthesis of four possible diastereomers. The acetyl derivative of the natural ceramide (1a) and synthetic ceramides (24−27) showed cytotoxicity on the human melanoma cell line SK-MEL-1, which was caused by induction of apoptosis as determined by DNA fragmentation, poly(ADP-ribose) polymerase cleavage, and procaspase-9 and -8 processing.en_US
dc.languageengen_US
dc.publisher0022-2623-
dc.relationNuevos Compuestos Antileucémicosen_US
dc.relation.ispartofJournal of Medicinal Chemistryen_US
dc.sourceJournal Of Medicinal Chemistry [ISSN 0022-2623], v. 49 (19), p. 5830-5839en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherMyeloid-Leukemia Cells
dc.subject.otherLanostanoid Triterpenes
dc.subject.otherApoptosis
dc.subject.otherActivation
dc.subject.otherInduction
dc.subject.otherCaspases
dc.subject.otherCancer
dc.subject.otherDeath
dc.titleIsolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cellsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/jm0605334en_US
dc.identifier.scopus33748861953-
dc.identifier.isi000240495600018-
dcterms.isPartOfJournal Of Medicinal Chemistry-
dcterms.sourceJournal Of Medicinal Chemistry[ISSN 0022-2623],v. 49 (19), p. 5830-5839-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid6603470039-
dc.contributor.authorscopusid7102211501-
dc.contributor.authorscopusid55366045300-
dc.contributor.authorscopusid22635323400-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid7101636723-
dc.description.lastpage5839en_US
dc.description.firstpage5830en_US
dc.relation.volume49en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000240495600018-
dc.contributor.daisngid136703-
dc.contributor.daisngid657275-
dc.contributor.daisngid244051-
dc.contributor.daisngid2952604-
dc.contributor.daisngid34941095-
dc.contributor.daisngid4276242-
dc.contributor.daisngid128315-
dc.contributor.daisngid384944-
dc.contributor.daisngid5695465-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDK-4656-2013-
dc.identifier.investigatorRIDK-5175-2014-
dc.identifier.investigatorRIDD-5184-2009-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.contributor.wosstandardWOS:Leon, F-
dc.contributor.wosstandardWOS:Brouard, I-
dc.contributor.wosstandardWOS:Rivera, A-
dc.contributor.wosstandardWOS:Torres, F-
dc.contributor.wosstandardWOS:Rubio, S-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.date.coverdateSeptiembre 2006en_US
dc.identifier.ulpgcSíes
dc.description.jcr5,115
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.project.principalinvestigatorEstévez Rosas, Francisco Jesús-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0001-7633-1285-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRubio Sánchez, Sara-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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