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Please use this identifier to cite or link to this item: https://accedacris.ulpgc.es/handle/10553/43483
DC FieldValueLanguage
dc.contributor.authorHernández, Juan C.en_US
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorBrouard, Ignacioen_US
dc.contributor.authorTorres, Fernandoen_US
dc.contributor.authorRubio Sánchez, Saraen_US
dc.contributor.authorQuintana Aguiar, José Martínen_US
dc.contributor.authorEstévez Rosas, Francisco Jesúsen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.otherTorres Andon, Fernando-
dc.contributor.otherRubio, Sara-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherQuintana, Jose-
dc.contributor.otherBrouard, Ignacio-
dc.contributor.otherRubio Sánchez, Sara-
dc.contributor.otherLeon, Francisco-
dc.date.accessioned2018-11-21T15:31:20Z-
dc.date.available2018-11-21T15:31:20Z-
dc.date.issued2008en_US
dc.identifier.issn0968-0896en_US
dc.identifier.urihttps://accedacris.ulpgc.es/handle/10553/43483-
dc.description.abstractThis study was carried out to assess the cytotoxicity of several new synthetic steroidal saponins against the human myeloid leukemia cell lines (HL-60 and U937) and against human melanoma cells (SK-MEL-1). Several diosgenyl glycosides analyzed showed strong cell growth inhibition which was associated with alterations in cell cycle progression and induction of apoptosis. Studies of cytochrome c release and caspase-9 activation suggest a main role of the intrinsic pathway of apoptosis in the mechanism of cytotoxicity caused by this kind of compounds.en_US
dc.languageengen_US
dc.publisher0968-0896-
dc.relation.ispartofBioorganic and Medicinal Chemistryen_US
dc.sourceBioorganic & Medicinal Chemistry [ISSN 0968-0896], v. 16 (4), p. 2063-2076en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherSynthesisen_US
dc.subject.otherSpirostanic saponinsen_US
dc.subject.otherCytotoxicityen_US
dc.subject.otherApoptosisen_US
dc.subject.otherLeukemiaen_US
dc.subject.otherHuman melanoma cellsen_US
dc.subject.otherCytochrome c releaseen_US
dc.subject.otherCaspaseen_US
dc.titleSynthesis of novel spirostanic saponins and their cytotoxic activityen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.bmc.2007.10.089
dc.identifier.scopus39049148505-
dc.identifier.isi000254080900041-
dcterms.isPartOfBioorganic & Medicinal Chemistry-
dcterms.sourceBioorganic & Medicinal Chemistry [ISSN 0968-0896], v. 16 (4), p. 2063-2076-
dc.contributor.authorscopusid55205608000-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid6603470039-
dc.contributor.authorscopusid55366045300-
dc.contributor.authorscopusid22635323400-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid7101636723-
dc.description.lastpage2076-
dc.description.firstpage2063-
dc.relation.volume16-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000254080900041-
dc.contributor.daisngid1534854-
dc.contributor.daisngid136703-
dc.contributor.daisngid657275-
dc.contributor.daisngid2952604-
dc.contributor.daisngid34941095
dc.contributor.daisngid4276242-
dc.contributor.daisngid128315-
dc.contributor.daisngid384944-
dc.contributor.daisngid5695465-
dc.identifier.investigatorRIDD-5184-2009-
dc.identifier.investigatorRIDK-4656-2013-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDK-5175-2014-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.contributor.wosstandardWOS:Hernandez, JC
dc.contributor.wosstandardWOS:Leon, F
dc.contributor.wosstandardWOS:Brouard, I
dc.contributor.wosstandardWOS:Torres, F
dc.contributor.wosstandardWOS:Rubio, S
dc.contributor.wosstandardWOS:Quintana, J
dc.contributor.wosstandardWOS:Estevez, F
dc.contributor.wosstandardWOS:Bermejo, J
dc.date.coverdateFebrero 2008
dc.identifier.ulpgcSíes
dc.description.jcr3,075
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0001-7633-1285-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRubio Sánchez, Sara-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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