Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43405
Title: Immunohistopathological study of African swine fever (strain E-75)-infected bone marrow
Authors: Rodríguez Guisado, Francisco 
De las Mulas, J. M.
Herráez Thomas, Pedro Manuel 
Sanchez Vizcaino, J. M.
Fernández Rodríguez, Antonio Jesús 
UNESCO Clasification: 310907 Patología
Keywords: Tissues
Virus
Thrombocytopenia
Antigens
Pigs
Issue Date: 1996
Publisher: 0021-9975
Journal: Journal of Comparative Pathology 
Abstract: A study was made of the action of African swine fever virus (ASFV) on the bone marrow of 12 miniature pigs inoculated intramuscularly with the moderately virulent ASFV isolate E75 and killed 2 to 12 days after infection. A sequential description is provided of the histological lesions of the bone marrow in the experimental animals, which developed haemorrhagic lesions from 6 days after inoculation onwards. Immunohistochemical techniques were used to demonstrate the viral protein VP73 and immunoglobulins (IgG and IgM) in formalin-fixed and paraffin wax-embedded samples of bone marrow tissue. The immunohistological results, platelet counts, viraemia, and anti-ASFV immunoglobulin titres all indicated that thrombocytopoiesis impairment by direct viral action plays a role in the progressive thrombocytopenia characteristic of infection by moderately virulent ASFV isolates. (C) 1996 W.B. Saunders Company Limited
URI: http://hdl.handle.net/10553/43405
ISSN: 0021-9975
DOI: 10.1016/S0021-9975(96)80015-6
Source: Journal of Comparative Pathology[ISSN 0021-9975],v. 114, p. 399-406
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