Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43404
Title: Pathological and immunohistochemical studies of natural and experimental Mycoplasma bovis pneumonia in calves
Authors: Rodríguez Guisado, Francisco 
Bryson, D. G.
Ball, H. J.
Forster, F.
UNESCO Clasification: 310907 Patología
Keywords: Respiratory Syncytial Virus
Pasteurella-Haemolytica
Gnotobiotic Calves
Calf Pneumonia
Lungs, et al
Issue Date: 1996
Publisher: 0021-9975
Journal: Journal of Comparative Pathology 
Abstract: Lung tissues from calves naturally and experimentally infected with Mycoplasma bovis were subjected to histopathological and immunohistochemical examination. The latter was carried out with a monoclonal antibody raised against M. bovis, and an avidin-biotin-peroxidase complex (ABC) detection substrate system. Pulmonary lesions in naturally infected calves included exudative bronchopneumonia and extensive foci of coagulative necrosis surrounded by inflammatory cells. Experimentally infected lungs showed suppurative bronchiolitis and varying degrees of peribronchiolar mononuclear cell cuffing. M. bovis antigen in field cases was mainly detected at the periphery of the areas of coagulative necrosis, in necrotic exudates, and in close association with infiltrating macrophages and neutrophils. In lung tissue from calves with induced M. bovis pneumonia, antigen was located in epithelial cells, within inflammatory cells in airway lumina, and in alveolar walls. Other microbiological observations suggested that the ability of M. bovis to invade and cause lung parenchymal damage could be influenced by the participation of other pathogens. (C) 1996 W.B. Saunders Company Limited
URI: http://hdl.handle.net/10553/43404
ISSN: 0021-9975
DOI: 10.1016/S0021-9975(96)80037-5
Source: Journal of Comparative Pathology [ISSN 0021-9975], v. 115, p. 151-162
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