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Title: Coordinate Expression of Cytokeratins 7 and 20 in Feline and Canine Carcinomas
Authors: Espinosa de los Monteros y Zayas, Antonio 
Fernández Rodríguez, Antonio Jesús 
Millán, M. Y.
Rodríguez Guisado, Francisco 
Herráez Thomas, Pedro Manuel 
Martín De Las Mulas, J.
UNESCO Clasification: 310907 Patología
Keywords: Carcinomas
CK 7
CK 20
Issue Date: 1999
Publisher: 0300-9858
Journal: Veterinary Pathology 
Abstract: Forty-seven feline and 60 canine epithelial tumors were studied to test the coordinate expression of cytokeratin 7 (CK 7) and cytokeratin 20 (CK 20) using commercially available monoclonal antibodies and an avidin-biotin immunoperoxidase staining technique. Previously, the distribution of both cytokeratins was examined in normal tissues from 4 cats and 4 dogs. The pattern of distribution of CK 7 in normal tissues was similar, with minor differences, to that described in humans, whereas the reactivity pattern of CK 20 in cats and dogs was wider than that in humans. The subset of tumors strongly expressing CK 7 and CK 20 included pancreatic adenocarcinomas (100%), transitional cell carcinomas (75%), and endometrial carcinomas (67%) in the cat. None of the canine tumors had this immunophenotype. Feline (50%) and canine (56%) mammary gland carcinomas and canine cholangiocarcinomas (67%) were the only tumors presenting the CK 7 +/CK 20- immunophenotype, whereas the CK 7-/CK 20+ immunophenotype included thyroid carcinomas (100%), intestinal adenocarcinomas (60%), bronchioloalveolar carcinomas (50%), and renal carcinomas (50%) in the cat and intestinal adenocarcinomas (56%), gastric adenocarcinomas (50%), and ovarian carcinomas (50%) in the dog. The CK 7-/CK 20- immunophenotype included the rest of the analyzed tumors. The immunohistochemical evaluation of coordinate expression of both CK 7 and CK 20 in feline and canine carcinomas using monoclonal antibodies provides important information that can help to discriminate among carcinomas from different primary sites and could be particularly helpful in the determination of the primary site of origin of carcinomas presenting as metastatic disease
ISSN: 0300-9858
DOI: 10.1354/vp.36-3-179
Source: Veterinary Pathology [ISSN 0300-9858], v. 36 (3), p. 179-190
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