Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/43384
Título: Changes in lymphocyte subsets in the bronchus-associated lymphoid tissue of goats naturally infected with different Mycoplasma species
Autores/as: Rodríguez Guisado, Francisco 
Fernández Rodríguez, Antonio Jesús 
Orós Montón, Jorge Ignacio 
Ramírez Corbera, Ana Sofía 
Luque, R.
Ball, H. J.
Sarradell, J.
Clasificación UNESCO: 320505 Enfermedades infecciosas
310907 Patología
Palabras clave: Bronchus associated lymphoid tissue (BALT)
Goat
Mycoplasma species
Fecha de publicación: 2001
Editor/a: 0931-1793
Publicación seriada: Journal of Veterinary Medicine Series B: Infectious Diseases and Veterinary Public Health 
Resumen: The distribution of cells containing lysozyme, S-100 protein, CD3, CD4, CD8, major histocompatibility complex class II antigen and immunoglobulin G (IgG) was analysed in the bronchus-associated lymphoid tissue (BALT) of goats naturally infected with three Mycoplasma species. This study included the immunohistochemical characterization of the pneumonic lesions of 18 goats (3-5 months old) infected with one of the following Mycoplasma species: M. mycoides ssp. mycoides, Large Colony type (goats no. 1-6), M. mycoides ssp. capri (goats no. 7-12) and M. capricolum ssp. capricolum (goats no. 13-18). Microscopically, infected animals showed a moderate broncho-interstitial pneumonia, characterized by lymphoid hyperplasia of the BALT and infiltration of mononuclear cells in the alveolar walls and airways. The main cellular type in the BALT was represented by CD3+ T lymphocytes, and the ratio of CD4+:CD8+ cells was > 2. The BALT showed large germinal centres mainly composed of IgG+ B lymphocytes, with numerous S-100+ follicular dendritic cells. The presence of follicular dendritic cells confirmed the high degree of organization of this lymphoid tissue. The immunohistochemical results showed that activated T lymphocytes, particularly in the CD4 subset, and IgG+ B cells, play a major role in the immune response of the caprine lung infected with these species of mycoplasmas.
URI: http://hdl.handle.net/10553/43384
ISSN: 0931-1793
DOI: 10.1046/j.1439-0450.2001.00434.x
Fuente: Journal of Veterinary Medicine, Series B [ISSN 0931-1793], v. 48, p. 259-266
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