Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43372
Title: Hepatosplenic large cell immunoblastic lymphoma in a bottlenose dolphin (Tursiops truncatus) with high levels of polychlorinated biphenyl congeners
Authors: Jáber Mohamad, José Raduán 
Pérez, J.
Carballo, M.
Arbelo Hernández, Manuel Antonio 
Espinosa de los Monteros y Zayas, Antonio 
Herráez Thomas, Pedro Manuel 
Muñoz, J.
Andrada Borzollino, Marisa Ana 
Rodríguez Guisado, Francisco 
Fernández Rodríguez, Antonio Jesús 
UNESCO Clasification: 310907 Patología
Keywords: Dolphin
Immunoblastic lymphoma
Lymphoma
PCB
Polychlorinated biphenyl, et al
Issue Date: 2005
Publisher: 0021-9975
Journal: Journal of Comparative Pathology 
Abstract: This report describes a large cell immunoblastic lymphoma in a bottlenose dolphin found stranded alive in Gran Canaria, Spain. Diffuse infiltration of round neoplastic cells was observed in the splenic cords and sinuses and in hepatic sinusoids, resulting in moderate organ enlargement. The tumour cells (immunophenotype IgG+ and CD3−) showed scant, lightly eosinophilic or basophilic cytoplasm, distinct cell boundaries and hyperchromatic nuclei, each with one or more nucleoli. Mitoses were common. On the basis of histopathological, immunohistochemical and ultrastructural features, the tumour was classified as an immunoblastic lymphoma. Eleven polychlorinated biphenyl (PCB) congeners, 23 organochlorine pesticides and 16 polycyclic aromatic hydrocarbons (PAHs) were detected in the blubber and liver. High concentrations of PCBs 153, 180, 138 and 187 found in the liver may have been associated with the hepatosplenic lymphoma.
URI: http://hdl.handle.net/10553/43372
ISSN: 0021-9975
DOI: 10.1016/j.jcpa.2004.09.009
Source: Journal of Comparative Pathology [ISSN 0021-9975], v. 132(2-3), p. 242-247
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