Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/43358
Título: Immunohistochemical localisation of 14-3-3 σ protein in normal canine tissues
Autores/as: Suarez Bonnet, Alejandro
Martin De Las Mulas Gonzalez-Albo,Juana
Herráez Thomas, Pedro Manuel
Rodríguez Guisado, Francisco
Espinosa de los Monteros y Zayas, Antonio
Clasificación UNESCO: 310907 Patología
Palabras clave: 14-3-3σ
Canine
Epithelial marker
Immunohistochemistry
Stratifin
Fecha de publicación: 2010
Editor/a: 1090-0233
Publicación seriada: Veterinary Journal 
Resumen: The 14-3-3 σ protein, also called stratifin, belongs to the highly conserved family of 14-3-3 acid proteins, which are involved in the modulation of diverse signal transduction pathways. Loss of 14-3-3 σ expression has been observed in several types of human cancers, suggesting that it may have a role as a tumour suppressor gene. The 14-3-3 σ protein has been localised in normal human tissues exclusively in various epithelial cell types. The aim of the study was to investigate the expression and the distribution pattern of 14-3-3 σ by immunohistochemical analysis in normal canine tissues. Immunohistochemical expression of 14-3-3 σ was demonstrated in several normal canine tissues with some minor differences of distribution pattern compared with human tissues. It appears that 14-3-3 σ is a very specific epithelial cell marker in normal canine tissues.
URI: http://hdl.handle.net/10553/43358
ISSN: 1090-0233
DOI: 10.1016/j.tvjl.2009.05.014
Fuente: Veterinary Journal [ISSN 1090-0233], v. 185(2), p. 218-221
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