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http://hdl.handle.net/10553/43358
Título: | Immunohistochemical localisation of 14-3-3 σ protein in normal canine tissues |
Autores/as: | Suarez Bonnet, Alejandro Martin De Las Mulas Gonzalez-Albo,Juana Herráez Thomas, Pedro Manuel Rodríguez Guisado, Francisco Espinosa de los Monteros y Zayas, Antonio |
Clasificación UNESCO: | 310907 Patología |
Palabras clave: | 14-3-3σ Canine Epithelial marker Immunohistochemistry Stratifin |
Fecha de publicación: | 2010 |
Editor/a: | 1090-0233 |
Publicación seriada: | Veterinary Journal |
Resumen: | The 14-3-3 σ protein, also called stratifin, belongs to the highly conserved family of 14-3-3 acid proteins, which are involved in the modulation of diverse signal transduction pathways. Loss of 14-3-3 σ expression has been observed in several types of human cancers, suggesting that it may have a role as a tumour suppressor gene. The 14-3-3 σ protein has been localised in normal human tissues exclusively in various epithelial cell types. The aim of the study was to investigate the expression and the distribution pattern of 14-3-3 σ by immunohistochemical analysis in normal canine tissues. Immunohistochemical expression of 14-3-3 σ was demonstrated in several normal canine tissues with some minor differences of distribution pattern compared with human tissues. It appears that 14-3-3 σ is a very specific epithelial cell marker in normal canine tissues. |
URI: | http://hdl.handle.net/10553/43358 |
ISSN: | 1090-0233 |
DOI: | 10.1016/j.tvjl.2009.05.014 |
Fuente: | Veterinary Journal [ISSN 1090-0233], v. 185(2), p. 218-221 |
Colección: | Artículos |
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