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Title: Human rhinoviruses and enteroviruses in influenza-like illness in Latin America
Authors: Garcia, Josefina
Espejo, Victoria
Nelson, Martha
Sovero, Merly
Villaran, Manuel V.
Gomez, Jorge
Barrantes, Melvin
Sanchez, Felix
Comach, Guillermo
Arango, Ana E.
Aguayo, Nicolas
De Rivera, Ivette L.
Chicaiza, Wilson
Jimenez, Mirna
Aleman, Washington
Rodríguez Guisado, Francisco 
Gonzales, Marina S.
Kochel, Tadeusz J.
Halsey, Eric S.
UNESCO Clasification: 2420 Virología
242008 Virus respiratorios
Keywords: Rhinoviruses
Influenza-like illness
Latin America
Issue Date: 2013
Journal: Virology Journal 
Abstract: BACKGROUND: Human rhinoviruses (HRVs) belong to the Picornaviridae family with high similarity to human enteroviruses (HEVs). Limited data is available from Latin America regarding the clinical presentation and strains of these viruses in respiratory disease. METHODS: We collected nasopharyngeal swabs at clinics located in eight Latin American countries from 3,375 subjects aged 25 years or younger who presented with influenza-like illness. RESULTS: Our subjects had a median age of 3 years and a 1.2:1.0 male:female ratio. HRV was identified in 16% and HEV was identified in 3%. HRVs accounted for a higher frequency of isolates in those of younger age, in particular children < 1 years old. HRV-C accounted for 38% of all HRVs detected. Phylogenetic analysis revealed a high proportion of recombinant strains between HRV-A/HRV-C and between HEV-A/HEV-B. In addition, both EV-D68 and EV-A71 were identified. CONCLUSIONS: In Latin America as in other regions, HRVs and HEVs account for a substantial proportion of respiratory viruses identified in young people with ILI, a finding that provides additional support for the development of pharmaceuticals and vaccines targeting these pathogens.
ISSN: 1743-422X
DOI: 10.1186/1743-422X-10-305
Source: Virology Journal [1743-422X], v. 10 (305)
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