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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43066
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dc.contributor.authorHenríquez-Hernández, Luis Alberto
dc.contributor.authorPérez, Leandro Fernández
dc.contributor.authorHernández, Ana González
dc.contributor.authorde León, Antonio Cabrera
dc.contributor.authorDíaz-Chico, Bonifacio
dc.contributor.authorRosales, A. Murias
dc.date.accessioned2018-11-21T12:20:22Z-
dc.date.available2018-11-21T12:20:22Z-
dc.date.issued2010
dc.identifier.issn1877-7821
dc.identifier.urihttp://hdl.handle.net/10553/43066-
dc.description.abstractPurpose. The distribution of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms was investigated in 80 consecutive breast cancer patients treated with adjuvant chemotherapy Results Observed allelic frequencies were TSER, (2)0 55 and (3)0 45, MTHFR C677T, (C) 065 and (T) 035: p53 Arg72Pro, (Arg) 076 and (Pro) 024, MDR1 C3435T, (C) 051 and (T) 0.49 MTHFR C677T was found to be a strong predictor of the presence of multifocal tumour (odds ratio, 4 1, 95% CI, 1 1-15 7, P = 0 035) Conclusion Our data indicate that breast cancer patients with the C/C variant may Present multifocal tumour most frequently (C) 2010 Elsevier Ltd All rights reserved
dc.publisher1877-7821
dc.relation.ispartofCancer Epidemiology
dc.sourceCancer Epidemiology[ISSN 1877-7821],v. 34, p. 490-493
dc.subject.otherThymidylate Synthase Gene
dc.subject.otherMethylenetetrahydrofolate Reductase
dc.subject.otherRisk
dc.subject.otherFolate
dc.subject.otherDisease
dc.subject.otherMetabolism
dc.subject.otherExpression
dc.subject.otherGenotype
dc.subject.otherC3435T
dc.subject.otherDiet
dc.titleTYMS, MTHFR, p53 and MDR1 gene polymorphisms in breast cancer patients treated with adjuvant therapy
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.canep.2010.03.004
dc.identifier.scopus77955090112-
dc.identifier.isi000281217500021
dc.contributor.authorscopusid15829708200
dc.contributor.authorscopusid35741643100
dc.contributor.authorscopusid56881665800
dc.contributor.authorscopusid7006344449
dc.contributor.authorscopusid7003603506
dc.contributor.authorscopusid8717750700
dc.description.lastpage493
dc.description.firstpage490
dc.relation.volume34
dc.type2Artículoes
dc.contributor.daisngid465624
dc.contributor.daisngid795544
dc.contributor.daisngid2701767
dc.contributor.daisngid14738520
dc.contributor.daisngid1724161
dc.contributor.daisngid1964063
dc.contributor.wosstandardWOS:Henriquez-Hernandez, LA
dc.contributor.wosstandardWOS:Perez, LF
dc.contributor.wosstandardWOS:Hernandez, AG
dc.contributor.wosstandardWOS:de Leon, AC
dc.contributor.wosstandardWOS:Diaz-Chico, B
dc.contributor.wosstandardWOS:Rosales, AM
dc.date.coverdateAgosto 2010
dc.identifier.ulpgcSíes
dc.description.jcr1,182
dc.description.jcrqQ4
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.orcid0000-0002-0944-990X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNameFernández Pérez, Leandro Francisco-
crisitem.author.fullNameDíaz Chico, Juan Carlos-
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