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http://hdl.handle.net/10553/43066
| Title: | TYMS, MTHFR, p53 and MDR1 gene polymorphisms in breast cancer patients treated with adjuvant therapy | Authors: | Henríquez-Hernández, Luis Alberto Pérez, Leandro Fernández Hernández, Ana González de León, Antonio Cabrera Díaz-Chico, Bonifacio Rosales, A. Murias |
Keywords: | Thymidylate Synthase Gene Methylenetetrahydrofolate Reductase Risk Folate Disease, et al |
Issue Date: | 2010 | Publisher: | 1877-7821 | Journal: | Cancer Epidemiology | Abstract: | Purpose. The distribution of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms was investigated in 80 consecutive breast cancer patients treated with adjuvant chemotherapy Results Observed allelic frequencies were TSER, (2)0 55 and (3)0 45, MTHFR C677T, (C) 065 and (T) 035: p53 Arg72Pro, (Arg) 076 and (Pro) 024, MDR1 C3435T, (C) 051 and (T) 0.49 MTHFR C677T was found to be a strong predictor of the presence of multifocal tumour (odds ratio, 4 1, 95% CI, 1 1-15 7, P = 0 035) Conclusion Our data indicate that breast cancer patients with the C/C variant may Present multifocal tumour most frequently (C) 2010 Elsevier Ltd All rights reserved | URI: | http://hdl.handle.net/10553/43066 | ISSN: | 1877-7821 | DOI: | 10.1016/j.canep.2010.03.004 | Source: | Cancer Epidemiology[ISSN 1877-7821],v. 34, p. 490-493 |
| Appears in Collections: | Artículos |
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