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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43065
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dc.contributor.authorHenríquez-Hernández, Luis Alberto
dc.contributor.authorMurias-Rosales, Adolfo
dc.contributor.authorGonzález-Hernández, Ana
dc.contributor.authorde León, Antonio Cabrera
dc.contributor.authorDíaz-Chico, Nicolás
dc.contributor.authorFernández-Pérez, Leandro
dc.date.accessioned2018-11-21T12:19:56Z-
dc.date.available2018-11-21T12:19:56Z-
dc.date.issued2010
dc.identifier.issn1877-7821
dc.identifier.urihttp://hdl.handle.net/10553/43065-
dc.description.abstractPurpose To investigate the role of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms in breast cancer patients treated with 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy. Results Observed allelic frequencies were: TSER, (2) 0.54 and (3) 0.46; MTHFR C677T, (C) 0.59 and (T) 0.41; p53 Arg72Pro, (Arg) 0.73 and (Pro) 0.27; MDR1 C3435T, (C) 0.52 and (T) 0.48. MTHFR allele T and p53 allele Pro were strongly associated with toxicity due to chemotherapy (odds ratio, 7.1 (95% confidence interval, 1.4-36.1; p = 0.018) and 7.0 (95% confidence interval, 1.2-40.5; p = 0.029), respectively). Conclusion We introduced new data related to the contribution of p53 codon 72 to toxicity due to 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy in patients with breast cancer. (C) 2010 Elsevier Ltd. All rights reserved.
dc.publisher1877-7821
dc.relation.ispartofCancer Epidemiology
dc.sourceCancer Epidemiology[ISSN 1877-7821],v. 34, p. 634-638
dc.subject.otherAcute Lymphoblastic-Leukemia
dc.subject.otherMethylenetetrahydrofolate Reductase C677T
dc.subject.otherColorectal-Cancer
dc.subject.otherThymidylate Synthase
dc.subject.otherClinical-Practice
dc.subject.otherOvarian-Cancer
dc.subject.otherIn-Vivo
dc.subject.otherToxicity
dc.subject.otherPharmacogenomics
dc.subject.otherTherapy
dc.titleDistribution of TYMS, MTHFR, p53 and MDR1 gene polymorphisms in patients with breast cancer treated with neoadjuvant chemotherapy
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.canep.2010.06.013
dc.identifier.scopus77957240834-
dc.identifier.isi000283974700019
dc.contributor.authorscopusid15829708200
dc.contributor.authorscopusid6506456721
dc.contributor.authorscopusid24921512000
dc.contributor.authorscopusid7006344449
dc.contributor.authorscopusid25723175700
dc.contributor.authorscopusid6506777525
dc.description.lastpage638
dc.description.firstpage634
dc.relation.volume34
dc.type2Artículoes
dc.contributor.daisngid465624
dc.contributor.daisngid8797852
dc.contributor.daisngid17097957
dc.contributor.daisngid14738520
dc.contributor.daisngid1724161
dc.contributor.daisngid795544
dc.contributor.wosstandardWOS:Henriquez-Hernandez, LA
dc.contributor.wosstandardWOS:Murias-Rosales, A
dc.contributor.wosstandardWOS:Gonzalez-Hernandez, A
dc.contributor.wosstandardWOS:de Leon, AC
dc.contributor.wosstandardWOS:Diaz-Chico, N
dc.contributor.wosstandardWOS:Fernandez-Perez, L
dc.date.coverdateOctubre 2010
dc.identifier.ulpgcSíes
dc.description.jcr1,182
dc.description.jcrqQ4
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.orcid0000-0002-0944-990X-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNameDíaz Chico, Juan Carlos-
crisitem.author.fullNameFernández Pérez, Leandro Francisco-
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