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http://hdl.handle.net/10553/43059
Título: | The relationship between Dioxin-like polychlorobiphenyls and IGF-I serum levels in healthy adults: Evidence from a cross-sectional study | Autores/as: | Luzardo, Octavio P. Henríquez-Hernández, Luis Alberto Valerón, Pilar F. Lara, Pedro C. Almeida-González, Maira Losada, Antonio Zumbado, Manuel Serra-Majem, Lluis Álvarez-León, Eva Elisa Boada, Luis D. |
Palabras clave: | Growth-Factor-I Polychlorinated-Biphenyls Pcbs Hudson River Communities Binding Protein-3 Estrogenic Activity, et al. |
Fecha de publicación: | 2012 | Proyectos: | grant No. 21/99 from the Fundación Canaria de Investigación en Salud (FUNCIS) PI060601, Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo |
Publicación seriada: | PLoS ONE | Resumen: | Objective: Insulin-like growth factor I (IGF-I) and dioxin-like polychlorobiphenyls (DL-PCBs) have been associated with the pathogenesis of several diseases like cancer, diabetes and growth disorders. Because it has been suggested that organohalogenated contaminants could influence IGF-I levels in adults, the potential relationship between DL-PCBs and IGF-I serum levels was studied in 456 healthy adults from a representative sample of the general population of the Canary Islands (Spain).Design: Free circulating serum levels of IGF-I and IGFBP-3 were measured through an ELISA methodology, while the serum levels of the 12 DL-PCBs congeners (IUPAC numbers # 77, 81, 105, 114, 118, 123, 126, 156, 157, 167, 169, and 189) were measured by gas chromatography/mass spectrometry (GC-MS).Results: DL-PCBs 156 and 167, Total DL-PCBs body burden (Sigma PCBs: sum over the 12 measured DL-PCBs), and Total toxic burden (in terms of toxic equivalence to dioxins: Sigma TEQs) showed a trend of inverse association with IGF-I serum levels in the whole studied population. After adjusting for potential confounders, including gender, body mass index (BMI), age, and IGF-binding protein-3 (IGFBP-3), younger (18-45 years) women with lower BMI (<27 kg/m(2)) and detectable levels of DL-PCB-156 showed significantly lower IGF-I levels than those in the same age and BMI subgroup with non-detectable levels of DL-PCB-156 (p<0.001). Similarly, Sigma PCBs and Sigma TEQs showed a tendency to an inverse association with IGF-I levels in the same group of women (p = 0.017 and p = 0.019 respectively).Conclusions: These findings suggest that DL-PCBs could be involved in the regulation of the IGF-system in a way possibly influenced by gender, age and BMI. Although these results should be interpreted with caution, such circumstances could contribute to explain the development of diseases associated to the IGF system. | URI: | http://hdl.handle.net/10553/43059 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0038213 | Fuente: | PLoS ONE [ISSN 1932-6203], v. 7 (e38213) |
Colección: | Artículos |
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