Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43055
Title: Prediction of normal tissue toxicity as part of the individualized treatment with radiotherapy in oncology patients
Authors: Henríquez-Hernández, Luis Alberto 
Bordón, Elisa 
Pinar, Beatriz
Lloret, Marta
Rodríguez-Gallego, Carlos 
Lara, Pedro C.
Keywords: Breast-Cancer Patients
Peripheral-Blood Lymphocytes
Radiation-Induced Apoptosis
Human Skin Fibroblasts
Hyperfractionated Radical Radiotherapy
Normal-Cell Radiosensitivity
Initial Dna-Damage
Long-Term Toxicity
Cervical-Carcinoma
Clinical Toxicity
Issue Date: 2012
Publisher: 0960-7404
Journal: Surgical Oncology 
Abstract: Normal tissue toxicity caused by radiotherapy conditions the success of the treatment and the quality of life of patients. Radiotherapy is combined with surgery in both the preoperative or postoperative setting for the treatment of most localized solid tumour types. Furthermore, radical radiotherapy is an alternative to surgery in several tumour locations. The possibility of predicting such radiation-induced toxicity would make possible a better treatment schedule for the individual patient. Radiation-induced toxicity is, at least in part, genetically determined. From decades, several predictive tests have been proposed to know the individual sensitivity of patients to the radiotherapy schedules. Among them, initial DNA damage, radiation-induced apoptosis, gene expression profiles, and gene polymorphisms have been proposed. We report here an overview of the main studies regarding to this field. Radiation-induced apoptosis in peripheral blood lymphocytes seem to be the most promising assay tested in prospective clinical trials, although they have to be validated in large clinical studies. Other promising assays, as those related with single nucleotide polymorphisms, need to be validated as well. (C) 2011 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/10553/43055
ISSN: 0960-7404
DOI: 10.1016/j.suronc.2011.12.002
Source: Surgical Oncology[ISSN 0960-7404],v. 21, p. 201-206
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