Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43055
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dc.contributor.authorHenríquez-Hernández, Luis Alberto
dc.contributor.authorBordón, Elisa
dc.contributor.authorPinar, Beatriz
dc.contributor.authorLloret, Marta
dc.contributor.authorRodríguez-Gallego, Carlos
dc.contributor.authorLara, Pedro C.
dc.date.accessioned2018-11-21T12:17:00Z-
dc.date.available2018-11-21T12:17:00Z-
dc.date.issued2012
dc.identifier.issn0960-7404
dc.identifier.urihttp://hdl.handle.net/10553/43055-
dc.description.abstractNormal tissue toxicity caused by radiotherapy conditions the success of the treatment and the quality of life of patients. Radiotherapy is combined with surgery in both the preoperative or postoperative setting for the treatment of most localized solid tumour types. Furthermore, radical radiotherapy is an alternative to surgery in several tumour locations. The possibility of predicting such radiation-induced toxicity would make possible a better treatment schedule for the individual patient. Radiation-induced toxicity is, at least in part, genetically determined. From decades, several predictive tests have been proposed to know the individual sensitivity of patients to the radiotherapy schedules. Among them, initial DNA damage, radiation-induced apoptosis, gene expression profiles, and gene polymorphisms have been proposed. We report here an overview of the main studies regarding to this field. Radiation-induced apoptosis in peripheral blood lymphocytes seem to be the most promising assay tested in prospective clinical trials, although they have to be validated in large clinical studies. Other promising assays, as those related with single nucleotide polymorphisms, need to be validated as well. (C) 2011 Elsevier Ltd. All rights reserved.
dc.publisher0960-7404
dc.relation.ispartofSurgical Oncology
dc.sourceSurgical Oncology[ISSN 0960-7404],v. 21, p. 201-206
dc.subject.otherBreast-Cancer Patients
dc.subject.otherPeripheral-Blood Lymphocytes
dc.subject.otherRadiation-Induced Apoptosis
dc.subject.otherHuman Skin Fibroblasts
dc.subject.otherHyperfractionated Radical Radiotherapy
dc.subject.otherNormal-Cell Radiosensitivity
dc.subject.otherInitial Dna-Damage
dc.subject.otherLong-Term Toxicity
dc.subject.otherCervical-Carcinoma
dc.subject.otherClinical Toxicity
dc.titlePrediction of normal tissue toxicity as part of the individualized treatment with radiotherapy in oncology patients
dc.typeinfo:eu-repo/semantics/reviewes
dc.typeArticlees
dc.identifier.doi10.1016/j.suronc.2011.12.002
dc.identifier.scopus84861196000
dc.identifier.isi000308123600014
dc.contributor.authorscopusid15829708200
dc.contributor.authorscopusid24402677200
dc.contributor.authorscopusid6507421079
dc.contributor.authorscopusid7003855087
dc.contributor.authorscopusid6602114379
dc.contributor.authorscopusid7004374085
dc.description.lastpage206
dc.description.firstpage201
dc.relation.volume21
dc.type2Reseñaes
dc.contributor.daisngid465624
dc.contributor.daisngid2045042
dc.contributor.daisngid1285881
dc.contributor.daisngid802813
dc.contributor.daisngid603384
dc.contributor.daisngid591076
dc.contributor.wosstandardWOS:Henriquez-Hernandez, LA
dc.contributor.wosstandardWOS:Bordon, E
dc.contributor.wosstandardWOS:Pinar, B
dc.contributor.wosstandardWOS:Lloret, M
dc.contributor.wosstandardWOS:Rodriguez-Gallego, C
dc.contributor.wosstandardWOS:Lara, PC
dc.date.coverdateSeptiembre 2012
dc.identifier.ulpgces
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNameBordón Rodríguez, Elisa de los Reyes-
crisitem.author.fullNameRodríguez Gallego, José Carlos-
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