Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/43055
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Henríquez-Hernández, Luis Alberto | |
dc.contributor.author | Bordón, Elisa | |
dc.contributor.author | Pinar, Beatriz | |
dc.contributor.author | Lloret, Marta | |
dc.contributor.author | Rodríguez-Gallego, Carlos | |
dc.contributor.author | Lara, Pedro C. | |
dc.date.accessioned | 2018-11-21T12:17:00Z | - |
dc.date.available | 2018-11-21T12:17:00Z | - |
dc.date.issued | 2012 | |
dc.identifier.issn | 0960-7404 | |
dc.identifier.uri | http://hdl.handle.net/10553/43055 | - |
dc.description.abstract | Normal tissue toxicity caused by radiotherapy conditions the success of the treatment and the quality of life of patients. Radiotherapy is combined with surgery in both the preoperative or postoperative setting for the treatment of most localized solid tumour types. Furthermore, radical radiotherapy is an alternative to surgery in several tumour locations. The possibility of predicting such radiation-induced toxicity would make possible a better treatment schedule for the individual patient. Radiation-induced toxicity is, at least in part, genetically determined. From decades, several predictive tests have been proposed to know the individual sensitivity of patients to the radiotherapy schedules. Among them, initial DNA damage, radiation-induced apoptosis, gene expression profiles, and gene polymorphisms have been proposed. We report here an overview of the main studies regarding to this field. Radiation-induced apoptosis in peripheral blood lymphocytes seem to be the most promising assay tested in prospective clinical trials, although they have to be validated in large clinical studies. Other promising assays, as those related with single nucleotide polymorphisms, need to be validated as well. (C) 2011 Elsevier Ltd. All rights reserved. | |
dc.publisher | 0960-7404 | |
dc.relation.ispartof | Surgical Oncology | |
dc.source | Surgical Oncology[ISSN 0960-7404],v. 21, p. 201-206 | |
dc.subject.other | Breast-Cancer Patients | |
dc.subject.other | Peripheral-Blood Lymphocytes | |
dc.subject.other | Radiation-Induced Apoptosis | |
dc.subject.other | Human Skin Fibroblasts | |
dc.subject.other | Hyperfractionated Radical Radiotherapy | |
dc.subject.other | Normal-Cell Radiosensitivity | |
dc.subject.other | Initial Dna-Damage | |
dc.subject.other | Long-Term Toxicity | |
dc.subject.other | Cervical-Carcinoma | |
dc.subject.other | Clinical Toxicity | |
dc.title | Prediction of normal tissue toxicity as part of the individualized treatment with radiotherapy in oncology patients | |
dc.type | info:eu-repo/semantics/review | es |
dc.type | Article | es |
dc.identifier.doi | 10.1016/j.suronc.2011.12.002 | |
dc.identifier.scopus | 84861196000 | |
dc.identifier.isi | 000308123600014 | |
dc.contributor.authorscopusid | 15829708200 | |
dc.contributor.authorscopusid | 24402677200 | |
dc.contributor.authorscopusid | 6507421079 | |
dc.contributor.authorscopusid | 7003855087 | |
dc.contributor.authorscopusid | 6602114379 | |
dc.contributor.authorscopusid | 7004374085 | |
dc.description.lastpage | 206 | |
dc.description.firstpage | 201 | |
dc.relation.volume | 21 | |
dc.type2 | Reseña | es |
dc.contributor.daisngid | 465624 | |
dc.contributor.daisngid | 2045042 | |
dc.contributor.daisngid | 1285881 | |
dc.contributor.daisngid | 802813 | |
dc.contributor.daisngid | 603384 | |
dc.contributor.daisngid | 591076 | |
dc.contributor.wosstandard | WOS:Henriquez-Hernandez, LA | |
dc.contributor.wosstandard | WOS:Bordon, E | |
dc.contributor.wosstandard | WOS:Pinar, B | |
dc.contributor.wosstandard | WOS:Lloret, M | |
dc.contributor.wosstandard | WOS:Rodriguez-Gallego, C | |
dc.contributor.wosstandard | WOS:Lara, PC | |
dc.date.coverdate | Septiembre 2012 | |
dc.identifier.ulpgc | Sí | es |
dc.description.sjr | 0,796 | |
dc.description.jcr | 2,136 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q2 | |
dc.description.scie | SCIE | |
item.fulltext | Sin texto completo | - |
item.grantfulltext | none | - |
crisitem.author.dept | GIR IUIBS: Medio Ambiente y Salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Médicas y Quirúrgicas | - |
crisitem.author.orcid | 0000-0003-3237-0316 | - |
crisitem.author.orcid | 0000-0002-4344-8644 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Henríquez Hernández, Luis Alberto | - |
crisitem.author.fullName | Bordón Rodríguez, Elisa de los Reyes | - |
crisitem.author.fullName | Rodríguez Gallego, José Carlos | - |
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