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Title: In vitro evaluation of oestrogenic/androgenic activity of the serum organochlorine pesticide mixtures previously described in a breast cancer case-control study
Authors: Figueroa Rivero, Javier 
Luzardo, Octavio P. 
Henríquez-Hernández, Luis A. 
Machín, Rubén P.
Pestano, José 
Zumbado, Manuel 
Boada, Luis D. 
Camacho, María 
Valerón, Pilar F. 
UNESCO Clasification: 3308 Ingeniería y tecnología del medio ambiente
3212 Salud pública
3214 Toxicología
Keywords: Endocrine disruption
Human breast cancer cells, et al
Issue Date: 2015
Publisher: 0048-9697
Journal: Science of the Total Environment 
Abstract: Some organochlorine pesticides (OCs) have been individually linked to breast cancer (BC) because they exert oestrogenic effects on mammary cells. However, humans are environmentally exposed to more or less complex mixtures of these organochlorines, and the biological effects of these mixtures must be elucidated. In this work we evaluated the in vitro effects exerted on human BC cells by the OC mixtures that were most frequently detected in two groups of women who participated in a BC case–control study developed in Spain: healthy women and women diagnosed with BC. The cytotoxicity, oestrogenicity, and androgenicity of the most prevalent OC mixtures found in healthy women (H-mixture) and in BC patients (BC-mixture) were tested at concentrations that resembled those found in the serum of the evaluated women. Our results showed that both OC mixtures presented a similar oestrogenic activity and effect on cell viability, but BC-mixture showed an additional anti-androgenic effect. These results indicate that although the proliferative effect exerted by these mixtures on human breast cells seems to depend mainly on their oestrogenic action, the BC-mixture might additionally induce cell proliferation due to its anti-androgenic activity, therefore increasing the carcinogenic potential of this mixture. The findings of this study demonstrate that subtle variations in the composition of a mixture may induce relevant changes in its biological action.
ISSN: 0048-9697
DOI: 10.1016/j.scitotenv.2015.08.016
Source: Science of the Total Environment[ISSN 0048-9697],v. 537, p. 197-202
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